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How to get good sleep with schizoaffective disorder?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello, Doctor,

I have schizoaffective disorder. I am taking the following medicines: Amisulpride 50mg, Fluvoxamine 25 mg, Clozapine 12.5 mg, Escitalopram 10 mg. Suddenly, I have started getting no sleep at night, like insomnia. I tried zolpidem, but it worked only for 2 days. Can you suggest getting good sleep?

Kindly help.

Thank you.

Answered by Dr. Kishan Mishra

Education:

MBBS

Professional Bio:

Dr. Kishan Mishra is a dedicated general practitioner committed to providing quality healthcare with a patient-focused approach. He is experienced in diagnosing and managing a variety of common medical conditions and believes in offering clear, practical, and effective treatment plans. Dr. Mishra is known for his calm and approachable nature, ensuring patients feel comfortable and well cared for during consultations. He focuses on preventive care, accurate diagnosis, and overall well-being, aiming to support patients in maintaining a healthy and balanced life through compassionate and professional medical care.      

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome to icliniq.com.

I read your query and can understand your concern.

Based on the prescription you have shared, I can see that you are taking two antipsychotic medications together, namely Amisulpride and Clozapine (both are atypical antipsychotic medicines). This is a combination that is sometimes used in the treatment of schizoaffective disorder. Both medications can cause sedation, which makes it somewhat unusual that you are experiencing significant insomnia.

I also notice that you are taking two selective serotonin reuptake inhibitors (SSRIs), Fluvoxamine and Escitalopram. This combination is relatively uncommon because both medications affect serotonin levels. Using them together may increase the risk of serotonin-related side effects and, therefore, requires careful monitoring by your psychiatrist.

Regarding Zolpidem (Non-benzodiazepine sedative-hypnotic), it may not have been the ideal long-term solution. Zolpidem can lead to tolerance within a relatively short period of time, meaning its effectiveness may decrease with continued use. It can also sometimes worsen psychiatric symptoms.

Your insomnia may also be influenced by your current medications. Both Fluvoxamine and Escitalopram can cause or worsen insomnia in some individuals. In addition, the timing of when these medications are taken, whether in the morning or at night, can significantly affect sleep quality.

One possible option that could be discussed with your psychiatrist is replacing Escitalopram with Mirtazapine. Mirtazapine is often taken at bedtime and may help improve sleep while also treating depressive symptoms. Another option that may be considered by your psychiatrist is adjusting the dose of clozapine, as higher doses can sometimes have a greater sedative effect and may help with insomnia.

In addition to medication adjustments, you can do the following things;

  • Sleep hygiene measures may be helpful. Try to wake up at the same time every day, even after a poor night's sleep.

  • Avoid using phones, televisions, and other screens for at least one hour before bedtime, as the light from these devices can interfere with melatonin production.

  • Keep your bedroom cool, quiet, and dark. Avoid caffeine after midday.

  • A short relaxation routine before bed, such as slow breathing exercises or gentle stretching, may also help you fall asleep more easily.

If you are unable to fall asleep after about 20 minutes, it is often better to get out of bed briefly and do a calm, relaxing activity before returning to bed when you feel sleepy.

I hope this information helps you.

Feel free to ask further queries.

Thank you.

Medically reviewed by iCliniq medical review team
Published At July 6, 2026
Reviewed At July 8, 2026

Education:

MBBS

Professional Bio:

Dr. Kishan Mishra is a dedicated general practitioner committed to providing quality healthcare with a patient-focused approach. He is experienced in diagnosing and managing a variety of common medical conditions and believes in offering clear, practical, and effective treatment plans. Dr. Mishra is known for his calm and approachable nature, ensuring patients feel comfortable and well cared for during consultations. He focuses on preventive care, accurate diagnosis, and overall well-being, aiming to support patients in maintaining a healthy and balanced life through compassionate and professional medical care.      

This doctor is not available for online consultations on the platform anymore.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Education:

MBBS

Professional Bio:

Dr. Kishan Mishra is a dedicated general practitioner committed to providing quality healthcare with a patient-focused approach. He is experienced in diagnosing and managing a variety of common medical conditions and believes in offering clear, practical, and effective treatment plans. Dr. Mishra is known for his calm and approachable nature, ensuring patients feel comfortable and well cared for during consultations. He focuses on preventive care, accurate diagnosis, and overall well-being, aiming to support patients in maintaining a healthy and balanced life through compassionate and professional medical care.      

This doctor is not available for online consultations on the platform anymore.

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