Why do I have anxiety symptoms even after taking medications?

Q. Should I continue using SSRI for anxiety even if the issues persist?

Answered by
Dr. Subhan Ullah
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Nov 24, 2022 and last reviewed on: Sep 25, 2023

Hi doctor,

I am on Effexor XR 150 mg daily morning (for chronic anxiety and GAD), and Crestor 10 mg daily (for controlling the lipid profile), and recently the doctor has added Cozaar 50 mg daily (because of high blood pressure). I used mostly all types of SSRIs, but I found Efexor is the best for anxiety and has the least side effects. I am doing well on Effexor 150 mg to control the whole case of anxiety and do not think about changing, stopping, or even decreasing the dose. I have continued symptoms since I started Effexor 8 months ago which includes erectile dysfunctions, slight libido, anorgasmia, and a little semen when ejaculation. Also, I have abnormal sleeping during the night with waking up many times during the night or insomnia. Actually, I do not know of all the above symptoms from Effexor or Crestor. I tried Buspar 10 mg thrice daily, but it did not help much regarding those symptoms of sexual side effects, so I stopped it. Remeron has been excluded completely because of the very high weight gain ratio.

The options available to me here and still not used are Trazodone XL 150 mg daily before bedtime. What do you think about this option? Can it help with those symptoms? Is this medication safe overall? Or is it related to cardio disorders and problems with the valve over time? The other option is Cabergoline 0.5 mg twice weekly, Is this safe medication for the heart? And overall, on the body? Can I use it for the long term? About starting 50 mg Cozaar, can this medication encounter Effexor-induced high blood pressure? In your opinion, which one is better regarding erection, weight gain, and blood pressure control, Cozaar 50 mg or Micardis 40 mg? Because I saw that my blood pressure at night did not drop enough.

Thank you.



Welcome to icliniq.com.

I read your case, and I found you are concerned about your treatment regimen and comorbid conditions. I found still you are taking Effexor 150 for GAD, and you continue to feel anxiety symptoms as well as sexual dysfunction and sleep disturbance. In my opinion, after reading your case, you may choose to change your regimen. You should take, tablet Wellbutrin XL 150 mg once daily. It has a side effect profile less severe than Effexor 150. If I consider your side effects like sexual dysfunction and sleep disturbance, I prefer Well Butrinb XL 150mg over Effexor. It does decrease your weight, which is an advantage. It is activating drug. But it can increase blood pressure like Effexor, but the risk is somehow less than Venlafaxine. You can add Xanax 0.25mg. One tablet at an hour of sleep, for improvement and anxiety attacks. For Trazodone, I prefer it only for mild to moderate anxiety and insomnia. Still, in your case, where anxiety symptoms are persistent, you should take Trazodone as an add-on to some other antidepressants. My regimen of Wellbutrin and Xanax holds good promise for you. You must keep taking blood pressure-lowering drugs as well as cholesterol-lowering drugs as per need and prescribed by a physician. My regimen will also help you manage weight and blood pressure if properly taken as my advice. Besides lifestyle management with meditation and daily walking, counseling can provide relief.

Thank you.

Hi doctor,

Thank you for your reply.

I tried Wellbutrin before as well, and it did not work. I want to keep Effexor because it is wonderful for me, but I want an add-on medication. So what are your suggestions?

Thank you.



Welcome back to icliniq.com.

I think we need to get an appointment and discuss things in detail about various options and combinations. It is sometimes necessary to discuss the full profile of drugs before opting for them.

Thank you.

Was this answer helpful?


Same symptoms doesn’t mean you have the same problem. Consult a doctor now!

Related Questions:
Anxiety: an Everyday Occurrence or Is There Something More to It?

On-going stress and environmental factors also contribute to anxiety disorders ...   Read full

Having depression and not getting well with SSRI. Can you suggest any treatment?

Hi doctor, I am suffering from depression, anxiety, and OCD ... Please suggest me the treatment for depression ...   Read full

Will my anxiety relapse if I stop SSRI?

Initially, I was prescribed Paxil 20 mg, which helped treat my anxiety and depression but I started having side effects of weight gain, fatigue, and sexual dysfunction ...   Read full

Also Read Answers From:

ideaComprehensive Medical Second Opinion.Submit your Case

Also Read

PCOS and Liver Problems
The hormonal imbalances in polycystic ovary syndrome could cause liver diseases. Read the article to know the relationship between these medical conditions.  Read more»
Inferior Alveolar Nerve Lateralization Technique
The inferior alveolar nerve lateralization technique is a surgical lateralization technique to reposition the nerve. Read the article to know more about this.  Read more»
COVID-19 and Ebola: Similarities and Differences
This article gives a comparison and broader overview of the outbreak of the two deadliest diseases that showed a greater incidence over the last two decades.  Read more»

Ask your health query to a doctor online?

Ask a Psychiatrist Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.