How long do the effects of stem cell therapy lasts?

Hello,

Welcome to icliniq.com.

I can understand your concern.

Stem cell therapy for severe osteoarthritis is still considered experimental, and results can vary. It primarily helps reduce inflammation and pain, but true cartilage regrowth is minimal or very slow. Relief may last from several months to a couple of years, but it is usually not permanent.

In a 68-year-old patient with diabetes, there are additional concerns: healing may be slower, and there is a small risk of infection. Stem cell therapy is generally safe if done at reputable centers, but its effectiveness in advanced osteoarthritis is limited compared to early or moderate cases.

Given your father's severe condition, if stem cell therapy is chosen, it should be with the understanding that it may delay, but not eliminate, the need for total knee replacement. A full orthopedic consultation would be necessary to weigh the pros and cons carefully.

The Probable causes:

1. Age-related cartilage degeneration.

2. Mechanical wear and tear over time.

3. Comorbidities (diabetes) possibly worsen joint health.

Investigations to be done:

1. X-rays of both knees (weight-bearing views).

2. MRI (magnetic resonance imaging) if needed (to assess cartilage status).

3. Blood sugar control assessment (HbA1c).

4. General fitness evaluation for potential surgical or regenerative procedures.

Differential diagnosis:

1. Inflammatory arthritis (like rheumatoid arthritis).

2. Post-traumatic arthritis.

3. Other causes of joint pain (e.g., gout, septic arthritis).

Probable diagnosis:

1. Severe bilateral osteoarthritis of the knees secondary to degenerative changes.

Treatment plan:

1. Optimize blood sugar control before any intervention.

2. Consider a trial of conservative management: physiotherapy, targeted injections (steroids, hyaluronic acid).

3. Discuss the pros and cons of stem cell therapy (limited cartilage regrowth, temporary pain relief).

4. Prepare for eventual total knee replacement if functional impairment persists.

5. Pain management optimization to avoid overuse of opioids or NSAIDs (non-steroidal anti-inflammatory drugs), especially in diabetics.

Regarding follow-up:

1. Regular orthopedic follow-up every three to six months.

2. Monitor response to any therapy attempted (clinical and imaging).

3. Preoperative planning for/when total knee replacement becomes necessary.

Preventive measures:

1. Weight management.

2. Low-impact exercises (like swimming and cycling).

3. Strengthening exercises for the surrounding muscles.

4. Regular monitoring of diabetes to slow joint deterioration.

I hope this helps.

Kindly follow up if you have more concerns.

Thank you.