Will babies need lifelong care after a stem cell transplant?

Question

Hello Doctor,

My newborn was just diagnosed with SCID (severe combined immunodeficiency), and the doctors are saying he needs a stem cell transplant soon. We are very scared because he is so little, and we do not know what to expect. How do they do the transplant in such young babies? Also, if he gets the new stem cells, does that mean he will have a normal immune system forever, or will he still have to be careful around infections?

Kindly help

Answer 1

Hello,

Welcome to icliniq.com.

I am sorry to hear about your newborn's diagnosis. Severe Combined Immunodeficiency (SCID) is a serious condition, but there is hope. A stem cell transplant can provide a chance for your baby to develop a functioning immune system. The process involves several steps, starting with preparation, where the baby may receive chemotherapy or radiation to eliminate the faulty immune cells. Next, stem cells are collected from a compatible donor, which could be a sibling or an unrelated donor. Once the stem cells are ready, they are infused into the baby's bloodstream through an IV (intravenous therapy). These cells then travel to the bone marrow, where they begin to generate new, healthy immune cells.

If the transplant is successful, the new stem cells will gradually create a working immune system, but this process takes time. It may take several months for your child's immune system to fully develop, during which extra precautions will be necessary to avoid infections. Regular follow-ups and careful monitoring will be essential to track progress and address any complications. If you have any concerns or would like more detailed information about the procedure, please feel free to book a consultation with me. I am here to support you through this journey.

I hope this helps.

Thank you.