Q. Will increasing the dosage of Topamax to 400 mg cause any adverse effect?

Answered by
Dr. Ruhi Satija
and medically reviewed by Dr. Divya Banu M
This is a premium question & answer published on Aug 25, 2019 and last reviewed on: Sep 16, 2020

Hello doctor,

I have been taking Topiramate 300 mg, along with Zyprexa 10 mg and Wellbutrin 400 mg as well as Clonazepam 0.5 mg three times a day. I have schizoaffective disorder and need to up my Zyprexa to 15 as I have been extremely irritable lately. However my Topiramate also serves me as an appetite suppressant and I am afraid that 15 mg of Olanzapine will cause a dramatic weight gain unless I also increase Topamax. Is it safe to increase Topamax to 400 gm?



Welcome to icliniq.com.

Increasing Olanzapine and Topiramate simultaneously is not a good idea. you can start with one medication at a time, or better idea would be to use Clonazepam more for the time being as I do not have details of your case, if your doctor is returning soon, you can manage the irritability with Clonazepam.

Thank you doctor,

So much for your answer. I have been taking this cocktail for the past 15 years, was in the hospital for three months, in the beginning, I actually started (my first doctor) with Zyprexa 15 mg, not 10. Clonazepam does not mitigate my irritability, only helps with anxiety (somewhat). And my irritability and anger are very severe as I have also been diagnosed with the intermittent explosive disorder. I am also very weight-conscious and desperately trying to lose weight. My only concern is Topiramate overdose as they say but I would only be going from 300 mg to 400 mg. So not a big jump and I have never had seizures. Can you please advise?



Welcome back to icliniq.com.

If that is the case you can go ahead, 400 is an acceptable dose, and please do follow up with your psychiatrist as soon as possible. Also, try some relaxation techniques which should help you, progressive muscle relaxation, box breathing technique, deep breathing exercises have a good effect if brought into daily practice.

Was this answer helpful?


Related Questions:
What is the treatment for delusion of jealousy?

.. is antipsychotic medicines like Olanzapine, Aripiprazole, etc., followed by insight oriented psychotherapy after remission. But, please ensure that there are no other symptoms like delusions of persecution or control, hearing voices, sleep and app...   Read full

Is PET scan necessary for epilepsy diagnosis?

.. childhood epilepsy (BCE) your child is on 6.25 mg/kg/day of tablet Topiramate (anticonvulsant) which is a medium dose and is fine. Side effect to look from Topamac is dehydration. For dehydration, he needs to drink at least 700-1000 mL water dail...   Read full

Is there any alternate method other than drugs to treat schizophrenia?

.. an antipsychotic medicine. Yes, Olanzapine is available in injectable form. If Olanzapine is causing some effects then it can be changed to other antipsychotic like Aripiprazole, Risperidone or Ziprasidone. You need to take medicines or injectable...   Read full


This is a sponsored Ad. icliniq or icliniq doctors do not endorse the content in the Ad.

7 Days COVID Care
Also Read Answers From:

Comprehensive Medical Second Opinion.Submit your Case

Also Read

Frequently Asked Questions About COVID-19 Vaccines
COVID-19 vaccines can be a real lifesaver. Read this to know the answers to the common questions and doubts on COVID-19 ...  Read more»
Female Sexual Arousal Disorder: Break the Shackles and Seek Help!!
This article throws light on Female Sexual Interest/Arousal Disorder, a common but least discussed sexual health topic a...  Read more»
Covaxin Vs Covishield
The coronavirus vaccines, Covaxin and Covishield, have received a green signal for restricted emergency use in India. In...  Read more»

Ask your health query to a doctor online?

Ask a Psychiatrist Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website.