tTG antibody is called tissue transglutaminase antibody. It is detected in celiac disease patients, an autoimmune disorder where the immune system gets triggering after taking gluten. This antibody is also detected in children having poor growth, diarrhea, vomiting, or rashes due to celiac disease. Tissue glutaminase is an enzyme that clears the damage in the body. The affected person with celiac disease develops antibodies that attack this enzyme, and so it is referred to as anti-tissue transglutaminase antibodies.
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Query: Hi doctor, My daughter, who is five years old, was detected with abdominal lymphadenopathy. Her ESR level is 62. She is also suffering from constipation and abdominal pain. Her doctor advised blood tests, ultrasound, and endoscopy followed by histopathology. The biopsy report shows chronic duoden... Read Full »
Answer: Hi, Welcome to icliniq.com. You should not worry. There is no evidence of cancer in the given scenario (attachment removed to protect patient identity). Lymph nodes (LN) in the abdomen are normal structures. The lymph nodes enlarge in the presence of infection and malignancy. Here, LN is not s... Read Full »
Query: Hi doctor, My daughter is 7 months old. She keeps pooping. She at least poops 20 diapers a day. Why? Read Full »
Answer: Hi, Welcome to icliniq.com. I can understand your concern. A baby of 7 months old passing stools of around 20 times a day is not normal. There are some diseases which can cause this type of symptom. The possibility of celiac disease should be ruled out. In celiac disease, there is an allergy to glu... Read Full »
Query: Hi doctor, I have celiac disease for the last ten years, but I was diagnosed recently a year ago. As I have switched to a gluten-free diet, I am feeling weak. I am 25 years old. Please suggest to me some gluten-free food. Now I am taking L-Glutamine supplement and Multivitamin to recover. Read Full »
Answer: Hi, Welcome to icliniq.com. You need to understand that giving supplements of whatever quality would not help unless your primary issue is settled. I am sure you would have done confirmatory tests for diagnosing celiac disease, namely tTG (tissue transglutaminase) and duodenal biopsy showing v... Read Full »
Query: Hi doctor, I am a 29 year old female working as a banker in a rural area. I used to eat slate pencils. I stopped it for the last six months as I experienced nausea, vomiting and passing loose stools. Since then, my hemoglobin level dropped to 7%. If I eat outside food, I suffer from loose stools and... Read Full »
Answer: Hi, Welcome to icliniq.com. We are here to help you. It does not look like a result of eating slate pencils. You either have hyperthyroidism or could be a result of irritable bowel syndrome (IBS). This needs to be evaluated by a battery of tests including blood sugar, thyroid profile, stool test, a... Read Full »
Query: Hello doctor, About 18 months ago, my stomach distended, and my stool turned from brown to light brown and eventually yellow. After that, I started to lose weight at a rapid rate, 40 lbs in 15 months. I was given multiple blood tests, an upper endoscopy, and abdominal ultrasounds. The only thing of... Read Full »
Answer: Hello, Welcome to icliniq.com. The cause of your weight loss could be maldigestion, malabsorption or systemic illness. Improper digestion occurs due to a lack of pancreatic enzymes secretion. Malabsorption occurs due to intestinal issues, for example, Celiac disease, infection or inflammation of t... Read Full »
Query: Hello doctor, My tissue transglutaminase IgA are high but I have not done any biopsy but done only an endoscopy (normal). If my TTG IgA is high then I must be having celiac disease because this level only goes high with celiac disease, am I right? Then why do I need to go for biopsy as it is a pain... Read Full »
Answer: Hello, Welcome to icliniq.com. It is useful for comparison of severity of bowel involvement in raised antibody status. Raised IgA TTG level grade according to Marsh classification if your antibody level less on Marsh stage you may need a biopsy. If the patient is suffering from hypoglobulinemia ... Read Full »