Common "Tyrosine Kinase Inhibitor" queries answered by top doctors | iCliniq

Tyrosine Kinase Inhibitor

Tyrosine kinase inhibitors are drugs that inhibit tyrosine kinase. Tyrosine kinase is an enzyme that is responsible for the activation of proteins, cell growth, and division. And these enzymes can be too active in certain types of cancer so blocking them helps prevent cancer cells from growing. Some of the examples of tyrosine kinase inhibitors include Axitinib, Dasatinib, Erlotinib, and Pazopanib.

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Can Alpha Arbutin stop tyrosinase activity of the skin?

Query: Hi doctor, Here is the problem: It appeared that I stopped the "tyrosinase" activity of my skin with a product called "Alpha Arbutin", mistaking it with an other product. Since, the melanin on the highest surface of my skin completely dissapeared. I slightly begin a depression and a depersonalizati...  Read Full »


Dr. Deepti Shukla

Answer: Hello, Welcome to icliniq.com. I understand your concern as this can be cosmetically unacceptable. Do not worry I will help you with your concern. Now you mentioned that you applied Arbutin for sometime and it has resulted in development of white patch. Yes, Arbutin works by inhibiting Tyrosinase...  Read Full »

Please explain how Tukysa differs from other medications.

Query: Hi doctor, My mother is currently undergoing treatment for advanced breast cancer, and her oncologist has mentioned Tukysa as a potential addition to her regimen. Can you explain how Tukysa differs from other medications for advanced breast cancer, and what factors contribute to its suitability for ...  Read Full »


Dr. Sukhdev Garg

Answer: Hi,Welcome to icliniq.com.I read your query and understand your concern.Tukysa (Tucatinib) is a tyrosine kinase inhibitor of HER2 (a protein that causes cancer to grow fast). In vitro, Tucatinib inhibits phosphorylation of HER2 and HER3, resulting in inhibition of downstream MAPK (mitogen-activated ...  Read Full »

What are the treatment options for an ALK-positive patient?

Query: Hi doctor, My brother was diagnosed to have ALK positive before two years. He had brain and bone metastasis. He got a brain surgery, WBR and spine radiation. He was on Crizotinib for 10 months and after brain and bone metastasis progression he was on Ceritinib for 5 months. In the latest scan, the d...  Read Full »


Dr. Bharat Patodiya

Answer: Hello, Welcome to icliniq.com. I understand your plight. There are a few options more at this time if general condition is good. From the details it appears that chemotherapy is not exhausted yet and it can be utilized now. If only targeted agents are to be discussed, then Alectinib can ...  Read Full »

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