What are the next treatment options for my brother's condition?

Hi doctor,

My brother was diagnosed to have ALK positive before two years. He had brain and bone metastasis. He got a brain surgery, WBR and spine radiation. He was on Crizotinib for 10 months and after brain and bone metastasis progression he was on Ceritinib for 5 months. In the latest scan, the disease progression was seen again in bone and also there was a new brain metastasis. Unfortunately, in my country, there is no next generation inhibitor of Ceritinib. What are the options now? Is there any chance to use Crizotinib again? He has some bone fractures also. We are feeling helpless. He is just 35 only. Already, he had WBR twice. What are the next treatment options? When he was on Crizotinib, he felt very active. But, while on Ceritinib, he mostly used to stay on the bed. Kindly suggest some option.

Thank you so much for the reply doctor,

Currently, he is very weak. Alectinib is not available in my country. How to get it? Or shall we continue the same drug and do radiation to the bone? Do you know any clinical trials of targeted therapy after Ceritinib? Kindly reply.