I have ulcerative colitis. Are biologics safe long-term?

Hello,

Welcome to icliniq.com.

I understand your concern.

Your colonoscopy and tests suggest active ulcerative colitis, even if symptoms feel mild. This situation is not uncommon. Tests such as fecal calprotectin and C-reactive protein (CRP) help measure inflammation in the colon.

A calprotectin level around 420 usually indicates ongoing intestinal inflammation, meaning the disease is still active despite relatively mild symptoms.

Because of this, your doctor recommended Adalimumab (Humira), a biologic therapy. These medications target specific inflammatory pathways in the immune system, particularly the molecule TNF-alpha (tumor necrosis factor), which plays a major role in ulcerative colitis inflammation.

Biologics are often considered when standard medicines like Mesalamine or steroids do not fully control disease activity, or when tests show persistent inflammation.

Although injections may sound like a strong treatment, they are commonly used today and can be very effective in inducing and maintaining remission and preventing long-term colon damage.

Regarding safety, biologics are generally well-tolerated with proper monitoring. Because they suppress part of the immune system, there is a slightly increased risk of infections, so doctors usually screen for tuberculosis and hepatitis before starting therapy.

Regular follow-up and blood tests help ensure safety. Most patients can use these medications for many years with good outcomes. The goal of treatment is not only symptom relief but also healing of the intestinal lining, sometimes called “mucosal healing.”

Starting biologic therapy when inflammation persists can reduce future flares, complications, and the need for steroids.

Discuss any concerns with your gastroenterologist, but many patients with ulcerative colitis achieve long-term disease control and improved quality of life with biologic therapy.

I hope this helps.

Thank you.