Patient's Query
Hello doctor,
I have been dealing with ulcerative colitis for years now, but the last few months have been brutal. Constant cramps, bloody diarrhea about five to six times a day, and I have lost 10 pounds without trying. Steroids help in the short term, but as soon as I stop, flare-ups hit again. I am on Mesalamine, but I am wondering if I should switch to biologics. Also, is stress really making it worse? I am exhausted and cannot even eat properly without worrying about pain later. Are there any foods that actually help calm the gut?
Kindly help.
Hello,
Welcome to icliniq.com.
I understand your concern.
It sounds like you are going through a tough flare of ulcerative colitis (UC). The symptoms you describe, bloody diarrhea, abdominal cramping, and unintentional weight loss, show that your disease is active and not fully controlled on Mesalamine alone. Since your symptoms return as soon as you stop steroids, this likely represents steroid-dependent ulcerative colitis (UC), which means you need a stronger, longer-term treatment to maintain remission and prevent flare-ups.
In such cases, biologic or advanced therapies are the next recommended step. According to the latest American College of Gastroenterology (ACG) and American Gastroenterological Association (AGA) guidelines, options include anti-tumor necrosis factor (anti-TNF) agents (like Infliximab or Adalimumab), integrin blockers (Vedolizumab), Interleukin (IL)-12/23 inhibitors (Ustekinumab), and Janus kinase (JAK) inhibitors (Tofacitinib or Upadacitinib). These medicines do not just ease symptoms; they target the immune response driving inflammation and can help heal the colon lining, reduce hospitalizations, and prevent long-term complications. Your doctor would screen for infections like tuberculosis and hepatitis before starting any of these, and regular blood work helps ensure safety.
Stress absolutely can make ulcerative colitis (UC) worse, though it does not directly cause it. Chronic stress increases inflammatory signals and can trigger flares, so stress management through relaxation techniques, gentle exercise, or mindfulness can be surprisingly helpful alongside medication.
As for diet, there is no single food plan that cures ulcerative colitis (UC), but some approaches can reduce discomfort. During a flare, many patients benefit from a low-residue (low-fiber) diet, which means avoiding raw fruits, vegetables, nuts, seeds, and whole grains to reduce bowel irritation. Stick with soft, easily digested foods like rice, oatmeal, potatoes, eggs, and lean protein. Once remission is achieved, shifting to a Mediterranean-style diet rich in omega-3 fats (like fish and olive oil) and low in processed foods helps maintain gut health. Avoiding lactose and limiting caffeine or spicy foods may also help if they worsen your symptoms.
You are not alone in feeling drained; active ulcerative colitis (UC) can cause fatigue and nutrient loss. Working closely with your gastroenterologist now to discuss starting a biologic or advanced therapy could make a major difference, both in controlling your disease and improving your quality of life.
I hope you are satisfied with my answer. For further queries, you can consult me at iCliniq.
Thank you.
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Answered byDr. Ahsanullah Niazai
Medically reviewed byiCliniq medical review team
Same symptoms don't mean you have the same problem. Consult a doctor now!
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