Welcome to icliniq.com.
I would like to know if it is pain, burning, or itching.
Is it associated with sexual activity?
Since your wife's urine examination and vaginally swab are fine, and you have completed the course of Fluconazole, there is a possibility that it is not yeast. Yeast infection is associated with intense itching in the vulvar region, cottage cheese-like discharge, and burning at the end of urination. But since you have completed the course of Fluconazole and there are still symptoms, we will also look into other causes.
Vaginal yeast is very common, and it can recur. Candida is the most common infection, so it can be there in the vagina, and some factors can make a female susceptible to frequent infection.
You can get checked her blood sugar, and this is one of the commonest causes of vaginal infection. Burning can also be associated with an allergy to harsh chemicals in body wash. If possible, then get a urine culture done so that in case of a urinary tract infection, specific antibiotics can be given rather than any random antibiotic. If she had been examined clinically by a gynecologist, then they would have told you if she would have required a biopsy.
Ask her to take a few precautions as the vagina is very sensitive to infections.
1. Keep the vulvar area dry and free, as moisture favors candidal growth.
2. Avoid using harsh perfumed wash.
3. Avoid overwashing.
4. Wear loose cotton underpants.
5. Take plenty of fluids.
6. Do not douche the vagina. Avoid using perfumed lubes and practice sexual hygiene. Washing with water and emptying the bladder after intercourse would do.