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Causes of Psychosis - An Overview

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Psychosis is an unnatural mental condition that shows impairment in distinguishing between real and fantasy. Read the article to know more about psychosis.

Medically reviewed by

Dr. Vishal Anilkumar Gandhi

Published At December 20, 2022
Reviewed AtJuly 18, 2023

Introduction

Psychosis is simply known for disconnection from reality. Psychosis is not an illness but a combination of symptoms developing due to underlying psychological related disorders, medical conditions, and other substances. About one percent of the world population encounters a psychotic disorder. It is a problematic condition, mainly affecting adolescents between late teens and thirties. It causes a person to see the world differently by disrupting their thoughts and perceptions.

What Is Psychosis?

Psychosis is an abnormal cognitive condition in which a person experiences certain things contrary to reality. Psychotic people cannot distinguish what is real and what is not. They, at most times, have confused and disturbed thoughts and are unaware of their environment. A psychotic episode usually occurs as a prodromal symptom of mental illness such as schizophrenia and bipolar disorder. The usage of toxins, alcohol, or drug also accompanies it. These two signs feature psychosis.

  • Hallucination- It is the fallacious perception of visual, auditory, and other sensations.

  • Delusion- In simple terms, it is a false belief.

What Causes Psychosis?

Psychosis is a symptom rather than an illness. The cause of psychosis is not just one component but many factors and conditions. Hence, psychosis is categorized based on the fact of cause. The causes are based on incorporating primary psychosis using psychiatric conditions or illnesses such as bipolar disorder, schizophrenia, and major depression, while secondary by toxins, drugs, or general conditions.

Hereditary and Genetics can also be a cause of psychotic disorders. Psychosis may inherit from parents and siblings. However, certain studies are going on how genes are involved in psychosis.

Psychiatric Conditions:

The psychotic episode, the first sign of mental conditions, chiefly occurs in the absence of physical conditions. This incidence is attributable to the alteration in the functioning of the brain. Here comes the typical psychiatric illness exhibiting psychosis.

  • Schizophrenia: It is a severe global mental disorder affecting about twenty-four million people worldwide. The rate of incidence is one in 222 people. Schizophrenia is a chronic condition that affects and impairs one’s perception, comprehension, and thoughts. This impairment eventually interferes with behavior and daily activities. Therefore, the chronic condition demands treatment over a lifetime.

  • Bipolar Disorder: Often known as manic depression, it is a chronic mood disorder featuring mood swings ranging from low depressive to a high manic state. The person with bipolar disorder experiences either depression or heightened excitability. The mood episodes could progress, lasting for months to years. And a person with bipolar depression is more likely to have suicidal thoughts.

  • Major Depression: Major depression, so-called clinical depression, is a chronic disorder characterized as a low mood or depressed state over a prolonged period. Depression is significantly due to chemical imbalances in the brain. In addition, this subsequently brings on a loss of interest in daily activities.

Besides, psychotic symptoms might be seen in the following mental conditions.

  • Personality Disorders - Such as paranoid, borderline, and schizoid.
  • Post-traumatic Stress - Disorders developed from past trauma, such as stressful situations, and dangerous events.
  • Delusional Disorder - When a person has non-realistic and also impossible thoughts and situations for more than a month.
  • Obsessive-compulsive Disorder (OCD) - It leads to obsessive or excessive thoughts that cause repetitive behavior.
  • Dissociative Disorders - It is a mental disorder that leads to discontinuity and disconnection of memories, thoughts, actions, identity, and surroundings. This dissociative disorder escapes reality, and a person finds difficulty functioning in daily life.
  • Eating Disorders - Such as eating disorders like bulimia nervosa (binge eating and then trying methods to reduce extra weight ) and anorexia nervosa (abnormal low body weight).
  • Chronic Hallucinatory Psychosis - It is a term used for delusional and hallucinatory disorders. It is an inorganic subtype of psychosis, that usually differs from paranoid schizophrenia.
  • Schizoaffective Disorder - It is a mental health disorder that presents a combination of various schizophrenic symptoms, such as mood disorder, maniac or depression, delusions, and hallucinations.

Medical Conditions:

A wide variety of medical conditions can induce a psychotic episode, and this kind of psychosis is further termed secondary psychosis. And such medical illnesses are named below.

  • Delirium is an impairment of mental ability resulting in altered thinking and confusion.

  • Degenerative disorders such as Alzheimer's disease, Parkinson's disease, and dementia.

  • Epileptic disorders encounter a significant number of seizure attacks. This condition is termed postictal psychosis.

  • Malignancy or cancer in the brain.

  • Stroke or cerebrovascular accident, CVA.

  • A disease of protective covering, myelin sheath of nerve named multiple sclerosis.

  • Benign and malignant brain tumors.

  • Infectious diseases like AIDS (acquired immunodeficiency syndrome), encephalitis (inflammation in the brain and its membranes), syphilis (a bacterial infection acquired through sexual contact), and malaria (a disease transferred to humans from an infected mosquito’s bite).

  • Endocrinal disorders such as hypothyroidism, Cushing syndrome, and hypoparathyroidism. The psychosis associated with the thyroid hormones is entitled to myxedematous psychosis.

  • Menstrual psychosis is rare yet affects the thoughts and moods of women. This kind of psychotic episode is due to altered hormone levels.

  • Several women develop psychotic symptoms after giving birth to a child, referred to as postpartum psychosis.

  • Vitamin B12 nutritional deficiency.

  • Innate metabolic disorders like porphyria, Wilson’s disease, and homocysteinemia.

  • Electrolyte-based acquired metabolic disorders due to an increase or decrease in the levels of sodium, potassium, calcium, magnesium, and phosphate. Also, recurs in kidney and liver failures.

  • Hypoxia.

  • Huntington’s disease.

  • Narcolepsy is a sleep disorder in which rapid eye movement sleep is often interrupted.

  • DiGeorge syndrome is a chromosomal abnormality disorder.

  • Autoimmune disorders include sarcoidosis, systemic lupus erythematosus, and steroid-responsive encephalopathy.

  • Neurocysticercosis is an infectious disease of parasite cysticercosis.

Drugs:

Various legal and illegal psychoactive substances and drugs induce cognitive impairment resulting in psychosis. In addition, prolonged use or intoxication of those drugs would significantly exacerbate psychotic disorders. Psychosis due to the drug and alcohol presents extreme symptoms and even heightened suicidal thoughts. Therefore, the succeeding substances are specified to cause psychosis.

  • Cannabis: Cannabis suppresses the nervous system by affecting brain activity. A recent study demonstrates that cannabis is more probably to cause the psychotic disorder.

  • Stimulants: Amphetamine is a stimulant staging short and long-lasting psychotic disorders. Besides, it is illustrated that about 25 to 46 percent of Amphetamine users have psycho symptoms. Cocaine is also a stimulant suppressing brain activity.

  • Alcohol: Chronic alcohol consumption staging both intoxication and withdrawal carries psychosis. The incidence rate of psychosis is about three percent for alcoholics, who are more likely to have depression and suicide. The process is the distortion of neuronal membranes and deficiency of thiamine, leading to psychosis.

  • Drugs: Psychosis can also occur as an adverse side effect of certain prescribed drugs. Psychiatric drugs or antipsychotic drugs rarely influence cognition.

Abuse and Trauma:

People who came across abuse or sexual assault in the past have an increased risk of psychosis. Trauma also triggers psychotic episodes, and this type of psychosis is also known as brief reactive psychosis because its symptoms usually occur in response to some stressful and traumatic events of the past.

What Are the Indications of Psychosis?

  • Difficulty in thinking.

  • Disability to focus and concentration.

  • Seeing and hearing things others cannot.

  • Encountering false beliefs.

  • Impairment in paying attention.

  • Confused state at most times.

  • A sudden drop in performances.

  • Constriction in social circle and solitariness.

  • Strange expressions or no emotions.

  • Fantasy world.

How Can Psychosis Be Treated?

Psychosis treatment is done with various antipsychotic and antidepressant medications, along with electroconvulsive therapy (ECTs). The drugs usually include serotonin-norepinephrine reuptake inhibitors (SNRIs) or serotonin reuptake inhibitors (SSRIs), which belong to a class of medications used to treat depression, chronic pain, and anxiety disorders. Antipsychotic drugs are often prescribed in combination with antidepressants, which include:

  • Sertraline and Olanzapine.
  • Venlafaxine and Quetiapine.
  • Fluoxetine and Olanzapine.

In addition to the combination medicinal treatment, the doctor also uses electroconvulsive therapy in such cases. It is a medical procedure that is performed under general anesthesia. In this, the psychiatrist induces generalized seizures in the brain by applying electric currents. The treatment option is mainly chosen by the doctor only if all other medications fail to treat the case. ECTs are an effective treatment procedure for psychotic depression treatment in people.

Psychotic disorders are also treated by the psychiatrist using art and talking therapies to help people express their feelings and thoughts in various ways, and thus help them develop coping mechanisms to deal with their mental disorder.

Conclusion

Psychosis is one of the effectively manageable conditions if it is diagnosed early. This is because the interventions address the underlying condition and primary causes of psychotic episodes. Nevertheless, it is essential to identify those at higher risk and ensure they receive appropriate guidance and treatment to prevent further progression.

Frequently Asked Questions

1.

Can Stress Cause Psychosis?

A brief psychotic disorder can be triggered by extreme stress, including a traumatic accident or the death of a loved one. However, it is usually followed by a return to the prior level of function. The affected individual may or may not be aware of their strange behavior. This condition most commonly affects individuals in their 20s, 30s, and 40s.

2.

What Is the Most Common Psychosis?

Psychosis is an amalgamation of psychological symptoms that leads to losing contact with reality. The most common psychotic disorder is schizophrenia. However, many other psychotic illnesses comprise psychosis as their core symptom.

3.

Can Overthinking Cause Psychosis?

Overthinking can create stress and trigger mental breakdowns. However, it is not yet proven that it can cause psychosis. However, a study stated that schizophrenia could be caused by the person internalizing traumatic memories and recurrently thinking about them too much, which could be self-destructive.

4.

Can Psychosis Be Cured?

 
An episode of psychosis is curable, and it is commonly possible to recover. In addition, the earlier the affected people get treatment, the better the outcome. A study suggests that 25 % of individuals who develop psychosis will not have another psychotic episode, and another 50 % may get more than one psychotic episode, but they can live their everyday lives.

5.

Who Is at Risk for Psychosis?

People with certain conditions are more likely to develop psychosis. 
 
These include:
- Traumatic brain injury, including a stroke.
- Family history of schizophrenia, mood disorders, or other psychotic disorders.
- Condition of dementia, such as Alzheimer's disease.
- Brain tumor or cyst
- Misuse of alcohol and drugs.
- Certain prescription medications.
- Childhood brain trauma or infections.
- HIV (human immunodeficiency virus) and other infections.
- Genetic mutations.

6.

How Long Can Psychosis Last?

The affected person usually experiences psychosis for a short period. Often, this is associated with extreme stress. However, this is not the situation all of the time. Generally, the experience of psychosis will develop gradually over two weeks or less. The affected person is likely to fully recover within a few days or weeks, depending on the severity of their condition.

7.

What Is the Treatment of Choice for Psychosis?

For people with psychosis, there is often no simple and quick treatment for their psychosis. However, it can be managed with good support, and recovery can be achieved. Treatment modalities for psychosis include antipsychotic medication, talking therapy, arts therapies, and family intervention. However, the primary treatment for psychosis is antipsychotic drugs. Moreover, Clozapine is usually well tolerated and effective in resolving psychotic symptoms.

8.

Is Psychosis Bad for the Brain?

According to a study, untreated psychosis was biologically toxic to the brain. Hence, an untreated episode of psychosis could result in structural brain damage due to neurotoxicity. However, there is not enough evidence to conclude this.

9.

What Are the Initial Warning Signs of Psychosis?

Before experiencing apparent symptoms of psychosis, the young adult often feels distressing changes in thoughts and emotions. These early symptoms include:
- A person might feel like something odd is happening or feel confused between reality and imagination.
- Feel watched or not in complete control of their thoughts.
- Changes in perception include their eyes or ears playing tricks, seeing shadows or figures through the corners of their eyes, or hearing jumbled, incomprehensible voices.
 

10.

Is Psychosis a Lifetime Illness?

Psychosis is a treatable condition. According to some studies, psychotic disorders have a low lifetime prevalence. Some conditions, such as bipolar disorders and schizophrenia, remain a lifetime, though.

11.

How Serious Is Psychosis?

Psychosis is a severe mental disorder that can cause abnormal thinking and perceptions. One serious and life-threatening complication of psychosis is that some individuals experiencing a psychotic episode might cause self-harm. Moreover, suicidal thoughts and a high risk of suicide are also common among psychotic people.

12.

Can Lacking Sleep Cause Psychosis?

If the person has sleep problems, they will be more prone to anxiety, depression, or suicidal ideation. Hence, they will be more likely to suffer from psychotic episodes as poor sleep can trigger psychosis, paranoia, mania, or worsen existing symptoms.

13.

How to Prevent Psychosis?

The most productive way for psychosis prevention is by avoiding exposure to the risk-increasing factors that control the individual, such as using certain medications, avoiding alcohol and drugs, proper sleep, eating healthy nutritious food, doing regular physical activity, and spending time outside.

14.

At What Age Is Psychosis Common?

 
The development of psychosis is most common in adolescents. However, most of the first events of psychosis have onset in adulthood, before the age of 24. In particular, the psychosis develops after childhood and adolescence, before age 45 to 50. Furthermore, psychosis affects more men than women.
Dr. Vishal Anilkumar Gandhi
Dr. Vishal Anilkumar Gandhi

Psychiatry

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