HomeAnswersMedical Gastroenterologyacid refluxDoes a burning sensation in the epigastric region suggest Zollinger disease?

I have a burning sensation in the epigastric region. Is it Zollinger disease?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Answered by

Dr. Noushif. M

Medically reviewed by

iCliniq medical review team

Published At October 23, 2017
Reviewed AtDecember 7, 2023

Patient's Query

Hello doctor,

I am suffering from a burning sensation in the epigastric region since two months. It is gradually increasing. I took a PPI for 10 days. Then four days after stopping PPI, I tested for serum gastrin level and it was 110. Do I have Zollinger disease?

Answered by Dr. Noushif. M

Hello,

Welcome to icliniq.com.

  • Serum gastrin level should be checked and interpreted with caution as it needs overnight fasting, early morning testing and abstinence from acid-suppression medications, etc. It can go as high as up to 300 or 400 pg/mL with normal being up to 100 pg/mL in people who had a PPI (proton pump inhibitor) recently.
  • In Zollinger syndrome, it will be usually more than 1000 pg/mL. From the limited clinical information you have provided, it is clear that you do not have Zollinger syndrome.
  • Hence, do not get worried. I hope your symptoms are better with a PPI. You can modify your diet and use a PPI as and when needed like for three to five days, if you have more symptoms. I hope your query has been cleared.

For more information consult a medical gastroenterologist online --> https://icliniq.com./ask-a-doctor-online/medical-gastroenterologist

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Noushif. M
Dr. Noushif. M

Surgical Gastroenterology

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