Drug and Supplements

Pantoprazole - Uses, Dosage and Side Effects

Written by Dr. Vasantha K S and medically reviewed by iCliniq medical review team.


Pantoprazole belongs to a group of drugs called proton-pump inhibitors (PPI), which prevent the secretion of stomach acid. They are used in the treatment of ulcers, heartburn, and reflux.

By blocking the enzyme that produces acid, the acid production in the stomach is lowered, thus allowing the ulcers in the stomach and esophagus to heal, thus providing relief from the symptoms.


  • To heal duodenal and gastric ulcers.
  • To prevent ulcers from forming with the intake of pain-relief medications.
  • To treat reflux disease.
  • As part of triple therapy in H.pylori infection.
  • To treat Zollinger-Ellison syndrome (a condition in which there is over-production of gastric acid).

Possible Side Effects

Allergy: Those allergic to Pantoprazole may develop symptoms such as rashes, swelling of the throat, face or lips and inability to breathe. This is a medical emergency and warrants immediate attention.

Other possible side effects include:

With long-term use, there can be low magnesium levels and vitamin B 12 deficiency.


It is normally available in the form of delayed-release tablets or granules.

  • For healing esophageal ulcers and treating acid reflux, the recommended dose is 40 mg daily for four weeks.
  • To treat Zollinger-Ellison syndrome, the dosage is 40 mg twice daily.
  • They are also available in IV form for hospital use.

How to Take?

  1. Usually, it is taken without food for maximum benefit.
  2. It is preferably taken at the same time every day.
  3. Swallow the tablets whole without crushing or splitting them.


Do not take if:

- you are allergic to PPI.

- you have a severe liver disease.

- you are pregnant, planning for a pregnancy, or breastfeeding.

- you have serious symptoms such as blood in stool, recurrent vomiting, etc.

- you have low magnesium levels.

- you are at risk of osteoporosis.

- you have lupus.

- you take drugs for HIV, certain antivirals, anticoagulants or Methotrexate.

Advantages of Pantoprazole over Other PPIs

  1. Pantoprazole has been proven to improve reflux symptoms and rapidly heal ulcers, the effect being more long-lasting.
  2. It has a lower chance of drug interactions.
  3. It is safe and effective in those with renal and moderate liver disease.
  4. Pantoprazole can be given intravenously in patients who are vomiting.

For more information consult a pharmacologist online --> https://www.icliniq.com/ask-a-doctor-online/pharmacologist

Last reviewed at: 07.Sep.2018



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