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Pantoprazole - Uses, Dosage and Side Effects

Written by
Dr. Vasantha K S
and medically reviewed by iCliniq medical review team.

Published on Jun 13, 2018 and last reviewed on Sep 07, 2018   -  2 min read


This article talks about the drug Pantoprazole commonly used in the treatment of ulcers, heartburn, and reflux.

Pantoprazole - Uses, Dosage and Side Effects

Pantoprazole belongs to a group of drugs called proton-pump inhibitors (PPI), which prevent the secretion of stomach acid. They are used in the treatment of ulcers, heartburn, and reflux.

By blocking the enzyme that produces acid, the acid production in the stomach is lowered, thus allowing the ulcers in the stomach and esophagus to heal, thus providing relief from the symptoms.


Possible Side Effects

Allergy: Those allergic to Pantoprazole may develop symptoms such as rashes, swelling of the throat, face or lips and inability to breathe. This is a medical emergency and warrants immediate attention.

Other possible side effects include:

With long-term use, there can be low magnesium levels and vitamin B 12 deficiency.


It is normally available in the form of delayed-release tablets or granules.

How to Take?

  1. Usually, it is taken without food for maximum benefit.
  2. It is preferably taken at the same time every day.
  3. Swallow the tablets whole without crushing or splitting them.


Do not take if:

- you are allergic to PPI.

- you have a severe liver disease.

- you are pregnant, planning for a pregnancy, or breastfeeding.

- you have serious symptoms such as blood in stool, recurrent vomiting, etc.

- you have low magnesium levels.

- you are at risk of osteoporosis.

- you have lupus.

- you take drugs for HIV, certain antivirals, anticoagulants or Methotrexate.

Advantages of Pantoprazole over Other PPIs

  1. Pantoprazole has been proven to improve reflux symptoms and rapidly heal ulcers, the effect being more long-lasting.
  2. It has a lower chance of drug interactions.
  3. It is safe and effective in those with renal and moderate liver disease.
  4. Pantoprazole can be given intravenously in patients who are vomiting.

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Frequently Asked Questions


When Should You Take Pantoprazole?

Pantoprazole should be taken before food. This will decrease the acid levels in the stomach. So if it is taken before food, the food components will not irritate the gastric mucosa. Pantoprazole medication should be taken once a day. It should be swallowed along with the water.


What Are the Side Effects of Taking Pantoprazole?

The most common side effects of Pantoprazole are:
- Joint pain.
- Diarrhea.
- Headache.
- Nausea or vomiting.
- Stomach pain.
- Dizziness.
- Gas.


Can Pantoprazole Consumption Cause Weight Gain?

Some patients are noted to have an increase in weight gain after the consumption of Pantoprazole. It is known to happen along with swelling of the feet and joint pain. This could be an indication of severe complications of the kidney. If you experience an unusual increase in your weight, you should consult your doctor immediately.


What Drugs Can I Take Instead of Pantoprazole?

Pantoprazole is a proton pump inhibitor (PPI). You can consume other proton pump inhibitors as an alternative to Pantoprazole. The commonly prescribed drugs are:
- Omeprazole.
- Lansoprazole.
- Esomeprazole.
- Ranitidine.
- Antacids such as Mylanta and Maalox.


Is Pantoprazole a Painkiller Drug?

No, Pantoprazole is not a pain killer. It is a proton pump inhibitor (PPI) used to treat conditions like gastroesophageal reflux disease (GERD) and erosive gastritis. The pain caused during these conditions can be treated with Pantoprazole by reducing gastric acid secretion. You should consult a doctor before consuming this medication.


Does Pantoprazole Work Rapidly?

The time is taken for Pantoprazole to show its action ranges between two to six hours. The metabolism of Pantoprazole takes place in the liver. The symptoms might subside within three days. In order to achieve a complete relief, a duration of four weeks might require.


Is Pantoprazole Used for Gastritis?

Yes, Pantoprazole is used for gastritis. The burning sensation in the abdomen, nausea, and vomiting are the symptoms of gastritis. The consumption of Pantoprazole alleviates these symptoms.


How Long Should I Take Pantoprazole?

The doctors will prescribe Pantoprazole for eight weeks generally. If consumption of Pantoprazole is not effective even after eight weeks, then you have to consult your doctor for any changes in dosage or prescription of alternative medicine.


Should I Take Pantoprazole on an Empty Stomach?

Taking Pantoprazole on an empty stomach is more beneficial than taking it after food. It is a safe drug and has only a few side effects. There are no additional problems seen when Pantoprazole is consumed on an empty stomach.


How Long Does Pantoprazole Take to Work?

Pantoprazole a maximum of six hours to work. The minimum time taken for Pantoprazole to show its action is around two hours. The time taken for a drug to show its action is never constant. It might vary depending upon the age, physiological functions, and health condition of an individual.


How Does Pantoprazole Work?

The main purpose of giving Pantoprazole is to reduce gastric acid secretion. The gastric mucosa has a few specific cells called parietal cells. There will be a covalent bond formation of hydrogen and potassium components to these parietal cells. This will, in turn, result in the overall reduction of acids in the stomach.


Is It Safe to Take Pantoprazole for a Long Time?

The recommended duration of Pantoprazole might not be the same for all the patients. Some patients are advised to take Pantoprazole for a prolonged period of time to suppress severe symptoms. But, some patients would be asked to take Pantoprazole only during the occurrence of symptoms.


Why Should Pantoprazole Be Taken in the Morning?

It is good to take Pantoprazole in the morning, a few hours before eating your food. This will prevent the excessive irritation to your gastric mucosa. The levels of acid secretion will also be at a controlled level by the time you take your food. If the doctor recommends taking Pantoprazole twice a day, then you can take one pill in the morning and another pill in the evening.

Last reviewed at:
07 Sep 2018  -  2 min read




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