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Pantoprazole - Uses, Dosage and Side Effects

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Pantoprazole - Uses, Dosage and Side Effects

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This article talks about the drug Pantoprazole commonly used in the treatment of ulcers, heartburn, and reflux.

Medically reviewed by

Dr. K. Shobana

Published At June 13, 2018
Reviewed AtJanuary 3, 2024


Pantoprazole belongs to a group of drugs called proton-pump inhibitors (PPI), which prevent the secretion of stomach acid. They are used in the treatment of ulcers, heartburn, and reflux.

By blocking the enzyme that produces acid, the acid production in the stomach is lowered. It allows the ulcers in the stomach and esophagus to heal, thus providing relief from the symptoms.


Pantoprazole contains,

  1. Active Ingredient:Pantoprazole sodium.

  2. Other Ingredients:

  • Calcium stearate.

  • Crospovidone.

  • Hypromellose.

  • Iron oxide.

  • Mannitol.

  • Methacrylic acid copolymer.

Drug Group:

Pantoprazole is a proton pump inhibitor that helps treat peptic ulcers, gastroesophageal reflux disease (GERD), non-ulcer but acid-related dyspepsia, etc.

What Is Pantoprazole Used For?

  1. It helps heal duodenal and gastric ulcers.

  2. It prevents pain medication induced ulcers.

  3. It helps treat reflux disease.

  4. It is used as part of triple therapy in H.pylori infection.

  5. It treats Zollinger-Ellison syndrome (a condition in which there is overproduction of gastric acid).

Advantages of Pantoprazole over Other PPIs:

  1. Pantoprazole has proven effects of improving reflux symptoms and rapidly healing ulcers and the effects of Pantoprazole are more long-lasting.

  2. It has a lower chance of drug interactions.

  3. It is safe and effective in those with renal and moderate liver diseases.

  4. Pantoprazole can be given intravenously in patients who have severe vomiting.

How Does Pantoprazole Work?

Pantoprazole inhibits the final step in gastric acid production. This drug binds covalently to the H+/K+ ATP pump and inhibits gastric acid and basal acid secretion in the gastric parietal cell of the stomach. This covalent binding prevents acid secretion, and the number of hours it prevents acid secretion will depend on the dosage of the tablet.

Onset Of Action:

Pantoprazole has a rapid onset of action, and the maximum effect of the drug occurs between 2 and 6 hours after drug administration. This drug has a bioavailability of 77% and is metabolized in the liver and excreted via urine and feces.

Expiry Date:

Avoid using this medicine after it expires. You can verify the expiry date printed on the back of the pack before using the medicine.

What Is the Dosage and Administration of Pantoprazole?

Dosage and administration of Pantoprazole depends on the following,

  • Age of the patient.

  • Weight of the patient.

  • Medical condition.

  • Response to treatment.

Preparations and Doses:

The available forms of Pantoprazole for both adults and children are,

Pantoprazole Usual Dosage:

Pantoprazole Usual Dosage:

How to Use Pantoprazole?

  1. Before using the medicine, read the package label and follow all the instructions.

  2. Avoid taking this medicine in larger or smaller amounts or longer than the recommended period as it can cause serious side effects.

  3. Usually, it is taken without food for maximum benefit. When the doctor has prescribed the medicine, take it as directed by the doctor.

  4. It is preferably taken at the same time every day.

  5. Swallow the tablets as a whole without crushing or splitting them.

  6. Take this medication until the full prescribed dose is finished, and do not stop this drug abruptly. Take the entire course of this medicine, as advised by the doctor, as stopping the drug too early may not cure the disease.

Missed Dose:

Pantoprazole should be taken as instructed by the doctor, and in case you missed the dose, it can be taken as soon as you remember it. But if it is time for the next dose, you do not have to take the missed dose, and you can continue with your regular dosing schedule. Also, do not use an extra tablet in order to compensate for a missed one.

What Are the Drug Warnings and Precautions?

  1. Before using Pantoprazole, inform your doctor or pharmacist if you have been allergic to this medicine or you have experienced any other allergies to the inactive ingredients of this medicine. It is always better to speak to the doctor or pharmacist to know more information.

  2. Before using Pantoprazole, you should tell your doctor or pharmacist about your medical history (present and previous), especially of:

  • Severe liver disease.

  • Pregnancy, planning for a pregnancy, or breastfeeding.

  • Serious symptoms such as blood in stool, recurrent vomiting, etc.

  • Low magnesium levels.

  • Risk of osteoporosis.

  • Lupus.

  • Taking drugs for HIV, certain antivirals, anticoagulants, or Methotrexate.

    3. Before undergoing any surgery, always inform your doctor or dentist about all the prescription, nonprescription and herbal products you use to avoid future complications.

    4. Inform your doctor if you take Pantoprazole or similar drugs such as Lansoprazole, Omeprazole because taking similar medication will increase the risk of side effects, or it can cause an overdose.

    5. During pregnancy, Pantoprazole should be used only when clearly needed. So, discuss the risks and benefits of this medicine before usage with your doctor.

    6. Do not breastfeed while taking this medication because it can pass through the breast milk.

What Are the Side Effects of Pantoprazole?

  • Common Side Effects:

Some common side effects caused by Pantoprazole are,

  • Abdominal pain.

  • Headache.

  • Facial puffiness.

  • Chest pain.

  • Diarrhea.

  • Generalized swelling (edema).

  • Constipation.

  • Rash.

  • Gas.

  • Itching.

  • Nausea.

  • High blood sugar (hyperglycemia).

  • Photosensitivity.

  • Vomiting.

  • Joint pain.

  • Dizziness.

  • Abnormal heart rate.

  • Cramps.

  • Fatigue.

When these side effects are mild, they go away on their own within a few days. When they are more severe and do not go away, get medical help.

  • Other Side Effects:

  • Skin swelling.

  • Anterior ischemic optic neuropathy.

  • Atrophic gastritis.

  • Hepatic failure.

  • Pancreatitis.

  • Low white and red blood cells.

  • Stevens-Johnson syndrome.

  • Interstitial nephritis.

  • Low platelet count.

  • Muscle wasting.

  • Fatal toxic epidermal necrolysis.

  • Erythema multiforme.

  • Allergy: Those allergic to Pantoprazole may develop symptoms such as rashes, swelling of the throat, face, or lips, and difficulty to breathe. This is a medical emergency.

With long-term use, there can be low magnesium levels and vitamin B12 deficiency.

What Are the Drug Interactions of Pantoprazole?

  1. The effectiveness of some drugs tends to change when they are taken with any other drugs or herbal products. Drug interactions increase the risk of serious side effects and cause the medicines to work improperly.

  2. If this drug has been directed by the doctor, then the doctor or pharmacist may be already aware of all the possible drug interactions and may be closely monitoring you for them. So, it is important to tell the doctor and pharmacist about the prescription, non-prescription, and herbal tablets you are taking.

  3. While using this medicine, do not suddenly start or stop or change the dosage of any other drugs you are advised to take without the doctor's approval.

  4. The list of some drugs that may interact with Pantoprazole includes the following.

  • Erlotinib.

  • Nelfinavir.

  • Rilpivirine.

  • Atazanavir.

  • Afatinib.

  • Dasatinib.

  • Digoxin.

  • Delavirdine.

  • Edoxaban.

  • Itraconazole.

  • Ivacaftor.

  • Indinavir.

  • Ketoconazole.

  • Nilotinib.

  • Mesalamine.

  • Nisoldipine.

  • Pomalidomide.

  • Pazopanib.

  • Ponatinib.

  • Sofosbuvir.

  • Riociguat.

  • Venetoclax.

    5. These are not the only possible interactions of Pantoprazole. So, before using this product, tell the doctor about all the medicines you use.

    6. Always keep a list of all the products you use and share the list with your doctor and pharmacist to avoid the risk of serious complications.

What Are the Common Brand or Trade Names of Pantoprazole?

The common brand names of Pantoprazole are,

  • Tablet Protonix.

  • Tablet Pantop Fast 40.

  • Tablet Palio 10s.

  • Tablet Pan-40.

  • Tablet Pantocid-40.

  • Tablet Pantova 40 mg.

  • Tablet Aciban-40.

  • Tablet Pantix 40 mg.

  • Tablet Pantofix 40 mg.

  • Tablet Pentastar-40.

Frequently Asked Questions


When Should You Take Pantoprazole?

Pantoprazole should be taken before food. This will decrease the acid levels in the stomach. So if it is taken before food, the food components will not irritate the gastric mucosa. Pantoprazole medication should be taken once a day. It should be swallowed along with the water.


What Are the Side Effects of Taking Pantoprazole?

The most common side effects of Pantoprazole are:
- Joint pain.
- Diarrhea.
- Headache.
- Nausea or vomiting.
- Stomach pain.
- Dizziness.
- Gas.


Can Pantoprazole Consumption Cause Weight Gain?

Some patients are noted to have an increase in weight gain after the consumption of Pantoprazole. It is known to happen along with swelling of the feet and joint pain. This could be an indication of severe complications of the kidney. If you experience an unusual increase in your weight, you should consult your doctor immediately.


What Drugs Can I Take Instead of Pantoprazole?

Pantoprazole is a proton pump inhibitor (PPI). You can consume other proton pump inhibitors as an alternative to Pantoprazole. The commonly prescribed drugs are:
- Omeprazole.
- Lansoprazole.
- Esomeprazole.
- Ranitidine.
- Antacids such as Mylanta and Maalox.


Is Pantoprazole a Painkiller Drug?

No, Pantoprazole is not a pain killer. It is a proton pump inhibitor (PPI) used to treat conditions like gastroesophageal reflux disease (GERD) and erosive gastritis. The pain caused during these conditions can be treated with Pantoprazole by reducing gastric acid secretion. You should consult a doctor before consuming this medication.


Does Pantoprazole Work Rapidly?

The time is taken for Pantoprazole to show its action ranges between two to six hours. The metabolism of Pantoprazole takes place in the liver. The symptoms might subside within three days. In order to achieve a complete relief, a duration of four weeks might require.


Is Pantoprazole Used for Gastritis?

Yes, Pantoprazole is used for gastritis. The burning sensation in the abdomen, nausea, and vomiting are the symptoms of gastritis. The consumption of Pantoprazole alleviates these symptoms.


How Long Should I Take Pantoprazole?

The doctors will prescribe Pantoprazole for eight weeks generally. If consumption of Pantoprazole is not effective even after eight weeks, then you have to consult your doctor for any changes in dosage or prescription of alternative medicine.


Should I Take Pantoprazole on an Empty Stomach?

Taking Pantoprazole on an empty stomach is more beneficial than taking it after food. It is a safe drug and has only a few side effects. There are no additional problems seen when Pantoprazole is consumed on an empty stomach.


How Long Does Pantoprazole Take to Work?

Pantoprazole a maximum of six hours to work. The minimum time taken for Pantoprazole to show its action is around two hours. The time taken for a drug to show its action is never constant. It might vary depending upon the age, physiological functions, and health condition of an individual.


How Does Pantoprazole Work?

The main purpose of giving Pantoprazole is to reduce gastric acid secretion. The gastric mucosa has a few specific cells called parietal cells. There will be a covalent bond formation of hydrogen and potassium components to these parietal cells. This will, in turn, result in the overall reduction of acids in the stomach.


Is It Safe to Take Pantoprazole for a Long Time?

The recommended duration of Pantoprazole might not be the same for all the patients. Some patients are advised to take Pantoprazole for a prolonged period of time to suppress severe symptoms. But, some patients would be asked to take Pantoprazole only during the occurrence of symptoms.


Why Should Pantoprazole Be Taken in the Morning?

It is good to take Pantoprazole in the morning, a few hours before eating your food. This will prevent the excessive irritation to your gastric mucosa. The levels of acid secretion will also be at a controlled level by the time you take your food. If the doctor recommends taking Pantoprazole twice a day, then you can take one pill in the morning and another pill in the evening.
Dr. Vasantha. K. S
Dr. Vasantha. K. S



proton-pump inhibitorsheartburnpantoprazole side effectspantoprazolepeptic ulceracid reflux
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