I have been suffering from acne issues all of a sudden for five months. I and have consulted several dermatologists. I was put on several topical creams, and very recently on Isotretinoin 10 mg which did not work then I have put on Isotretinoin 20 mg this too has shown no results. I still have nodules, cystic, and resistant acne coming up. This is now affecting my mental health, as I have always had good skin. My reports for PCOD are normal. I am a 29-year-old female going to turn 30 next month. I am very depressed as I am losing hope if it will ever get cured as Isotretinoin being the last hope has also failed.