What does a positive ANA test in a diabetic patient indicate?

Q. My diabetic mother has fever, body and joint pain and the ANA test is positive. What is the reason?

Answered by
Dr. Salah Saad Hassan Shoman
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Oct 22, 2019

Hello doctor,

My mother is 65 years old. She is a diabetic. For the past one month, she had fever, body pain, and joint pain. After a while, her leg started swelling, and slowly the blood platelet count came to 28000. She got admitted to the hospital and was on Xone antibiotics and Dolo 650 with trips. Leg swelling slowly reduced and the platelet count reached 125000.

Four months before, she had a leg swelling and it got cured after taking some medicines prescribed by a doctor.

Basic creatinine, dengue, blood test, and scan were done. Light swelling in the liver and spleen is seen.

Dengue and other basic reports showed negative. Today we received a report positive (ANA), Pattern: Nuclear fine granular (strongly positive). This may be associated with SJS, SLE, neonatal LE, Polymyositis, dermatomyositis, progressive systemic sclerosis. Can you please advise.



Welcome to icliniq.com.

I have gone through your question and understood your concerns. Autoimmune attacks that lead to decreased platelet count (thrombocytopenia) are mostly associated with systemic lupus syndrome or can be associated with rheumatoid arthritis in case there is an associated joint involvement. I would recommend that you get an anti-lupus antibody testing and rheumatoid factor testing to confirm or exclude the diagnosis.

I hope this helps.

Thank you doctor,

Can you please advise whether it is curable and the reason for getting affected?



Welcome back to icliniq.com.

There are many theories for autoimmune diseases, including genetic predisposition and environmental triggers. However, none were conclusive. Autoimmune disorders are chronic diseases that can be put into remission by medications, while relapse attacks can occur during stress periods at any time.

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