What could be the reason for low white blood cells and anisocytosis after COVID-19 vaccination?

Hello doctor,

I have had a low white blood cell count for about 15 months. It hovers around the threshold for neutropenia and lymphopenia but is always down. A blood film today shows mild anisocytosis, which was also the case at least six months ago when it was last checked. I have been undergoing ozone treatments for the last two weeks. Maybe they affected the blood work. If things were normal, the white blood cells should be coming up quickly to a normal level. My baseline before this illness was around mid-range circulating WBC. I have seen slight improvement since I last checked in three months before. I am waiting for the beta 2 microglobulins result. Prolactin levels were high previously but are now back in the normal range. The blood test also showed platelet anisocytosis, rouleaux, and reactive lymphocytes. My question is, would a filgrastim shot help my system? Should I do flow cytometry or other tests?

Hello doctor,

Thank you for the reply.

EBV serology was positive but simply indicates a past infection. If it were active, maybe I would have different symptoms. It has been 17 months of recovering from an EBV infection. Everything began 14 hours after the COVID-19 vaccination. Previous to this illness, I was very strong and at the top of my career. Now I have lost everything because the symptoms stop me from working. I have read Prednisone can increase WBC. A rheumatologist tried a course of Prednisone for four weeks a year back because he suspected autoimmune neutropenia. The white blood cells did not increase, but the immunoglobulins normalized. I need something drastic to change. This is not fine for me. Numerous doctors do not know what to tell me, and I am fed up with it.

1. Is there significance in the platelet anisocytosis being there for so long now?
2. Are there any drugs that will help the white blood cells come back up to correct the immune system and get things under control?

I believe a low-dose shot of Neupogen or a derivative could correct my system finally. Then, I can buy it from the pharmacy. I am very, very tempted to go and do it.

Hello doctor,

Thank you for the reply.

I have tried all these nutrients through oral and injectable forms for extended periods and had no change. So we know the cause as a vaccine shot. I did not develop an EBV infection on the same day as the vaccination, but it may have reactivated an old EBV infection. I do not have any titer reading for EBV antibodies. My ongoing symptoms are strange and not explained by mental health issues such as anxiety or depression.

1. Is anisocytosis a significant problem?
2. Any idea what might have caused it for so long? Why are the red blood cells not being replaced and replenished with healthy cells?
3. Are they being replaced with more bad cells?

For months I have had left-sided chest pain through to the back ribs. It went away for a long time but came back when I took aspirin. Would this have anything to do with the spleen or liver? My ALT (alanine transaminase) has been elevated slightly for a long time.

My only other idea is taking somatotropin, or testosterone replacement, which might have a restorative effect. But I can get a low-dose self-injectable of Neupogen, which seems to be the quickest way out of this nightmare. I would do one dose, which might be enough to get me up and on top of whatever is happening. I plan to have a blood test tomorrow for B and T cell screening and ganglioside antibodies. Any other tests you think might help? A few months ago, I was negative for ANCA (anti-neutrophil cytoplasmic antibody).

In my estimation, this illness possibly comprises autoimmune issues, viral activity, viral debris, aluminum poisoning, and the contribution of psychological stress. I am also interested to know why you feel flow cytometry cannot help? I have done intense blood cleaning using ozone for over two weeks; the last one was seven days ago. Maybe that has caused more or renewed anisocytosis as Heparin is used in the treatment. But, I do not know what a normal increase or decrease in the time for white blood cells is. I suspect it happens gradually over a month or two, but I believe it should be quicker in healthy people.

Hello doctor,

Thank you for the reply.

The pain in my chest and back is more of a cramp or fatigue feeling rather than GERD. I am very experienced with GERD as suffered with it for many years due to over eating and a bad sugary diet. The filgrastim might just bring up the count. Should I be worried about any side effects? I also have cabergoline, due to high prolactin levels for six months but they seem to be back in the normal range again. Obviously I want to do the least risky of treatments to start with. Maybe I should renew the ANA (antinuclear antibody) profile before doing filgrastim in case any autoantibodies go crazy. It has been strange, when tested after two months post acute illness showed ANA positive 1:80, then a month later negative ANA, but positive anti-CCP (cyclic citrullinated peptide). With the anisocytosis, I think it is a normal reaction to all the intense treatments I have had recently. To be honest I would say I need to give my body a break for a few weeks before doing filgrastim. I want to bring my neutrophils up to the mid range. My choices are Cabergoline, Prednisolone, Filgrastim, Somatotropin, Euthyrox. I do seem to have stress reactions in my hand, leg and face with increased neuropathy type sensations.

Hi doctor,

Thank you for the reply.

I had more blood tests done during the week, the hematologist report contained, but WBC seem to have variation (which is not normal for me before vaccination). I have developed decreased WBC marginal idiopathic condition. So I tested for EBV IgM and was negative. But the immunology screening test has abnormal results. I also tested for copper and got results in normal range. Am I prone to chronic infection? I am anxious as I read on the internet. But I already tested negative for lyme and borrelia. I have got the Neupogen (Filgrastim) today, but will wait for feedback. Should I try a course of tablet Doxycycline? When tablet Doxycycline is combined with tablet Valtrex (Valaciclovir), will it produce excess neutrophils against COVID-19?

Thank you.

Hi doctor,

Thank you for the reply.

Will my white blood cell counts fall back into cytopenic ranges again? Because my friend told my reports suggest COVID-19 profile or Lyme disease. I have had muscle spasms, tinnitus, cervical spine problems, painful swollen facial nerve, migraine, swollen leg, burning sensation on the feet, weakness 12 hours after vaccination. Please help.

Thank you doctor for the reply,

It has been a nightmare and of course we have no idea how it will look in five or ten years. My concern now is using the tools I have to ameliorate the disease as best as I can. I took neupogen 30 IU and tablet Doxycycline 100mg. Some research claims tablet Doxycycline has some antiviral effects in COVID, so after reading an article about the eradication of lyme disease using a doxy equivalent with filgrastim. According to that, once my system gets used to the tablet Doxycycline (maybe on the day four or five), I will support the process using neupogen shots on the third to seventh day. I am expecting to react to the neupogen. Some patients were tested with tablet Ceftriaxone 2 g for seven days, then filgrastim every second day for seven days, then finally another seven days of tablet Ceftriaxone or filgratsim alternatively. Can it be combined? At this moment it would make sense to boost the system with fresh neutrophils after three or four days of fighting with tablet Doxycycline, and then again as the treatment completes on the sixth or seventh day, and may be then test for blood counts.

Thank you doctor for the reply,

I started the tablet Doxycycline and start neupogen within two days. After everything that has happened already I would imagine finding someone to help me with sensitivity testing would be impossible. So now we will see, another experiment on my body, this is what is happening to a huge number of vaccine injured people worldwide sadly. I know nothing about how filgrastim might affect the NK cells. I will take the test again in two weeks.

Hi doctor,

Thank you for the reply.

I am now on the sixth day of tablet Doxycycline. Symptoms have not changed, if anything a small bit worse, and some tiredness, but it is 40 degree heat here at present. I am hesitant to start Neupogen. Especially on the same day. I have come across research papers showing reduction in some types of NK cells after taking tablet Filgrastim. Another reason that is making me hesitant is that the vaccination has likely caused gene mutations (studies have shown this in the vector and mRNA based), and I am unsure whether tablet Filgrastim can also have this effect. I am aware a lot of gene mutation can greatly increase cancer risk. I do not have much knowledge. Is there a reason hematologists are hesitant to recommend tablet Filgrastim? So at the moment my plan is to either start the tablet Neupogen later today in between tablet Doxycycline, and do a second course tablet Neupogen. Or, finish the tablet Doxycycline on the seventh day, tomorrow, then begin the tablet Neupogen on sunday. I will repeat the test today. Adding tablet Hydroxychloroquine or tablet Ivermectin has also crossed my mind, as recommended by some clusters of doctors, I could take tablet Neupogen next week then repeat tablet Doxycycline together with tablet Ivermectin or tablet Hydroxychloroquine.

Thank you.

Thank you doctor for the reply,

I have attached the blood reports taken three after first dose of tablet Neupogen. I completed tablet Doxycycline course on Saturday. The WBC coundt raised than an expected level. Unfortunately I saw the results too late and used tablet Neupogen today. I am really worried whether the white blood cells will go into anemia state and results in spleen problems. How will these cells modulate? Will the spleen regulate them back to normal levels? After the first tablet Neupogen the random muscle spasming has now stopped.

Hello doctor,

Thank you for your response.

I guess it would be good to test the blood count again in a few weeks, allowing a chance for things to settle. I have noticed that muscle spasming has returned a lot, along with tingling over the past three days, which must be due to either finishing the Doxycycline, doing a second Neupogen injection, or the stress and overload of traveling (it was a long, arduous journey with little sleep and extreme temperature changes).

Thank you.

Hello doctor,

Thank you for your response.

1. Can you tell me more about the need for the medicines mentioned above?

2. I have a month's course on Amitryptiline and Lorazepam, and Propranolol. Which should I take, at what strength, and how often?

3. I also have Prednisolone and Methylprednisolone. So again, what do you think could be a helpful course?

4. Should I use any more filgrastim? I have three injections left.

5. What do you think the bone marrow biopsy will find?

6. Any ideas about the noisy ligaments?

Thank you.

Hello doctor,

Thank you for your response.

No, the noisy ligaments began with temporary orchitis and severe cervical neuralgia or trigeminal neuralgia pain and tinnitus following a depot injection given to me by a medical doctor using naturopathic methods months back. The cause was either a depot injection containing coq10 and acetylcholine or a Dexamethasone injection into the infraorbital nerve. I guess it exacerbated what was already happening.

I do not know what to do about the bone marrow biopsy. So you recommend trying prednisolone for four weeks, but the instruction is unclear. Do you mean 10 mg twice a day for a week, then 5 mg three times a day for a week, then 5 mg twice a day for a week, then 5 mg once a day for a week?

I feel completely powerless with my health now, if I am honest. I wonder whether my immune system will ever recover. I was never ill, and I have been continually ill for 20 months since the day after.

Kindly help.

Thank you.

Hello doctor,

I just wanted to update you about the Prednisolone and anxiolytic treatment.

I am taking 0.5 mg Lorazepam daily or every two days and Prednisolone as suggested. I am taking 5 mg twice daily, continuing to taper slowly. Unfortunately, I have not experienced much relief, generally speaking, but I feel the tinnitus has been reduced. I find my reaction to stress, such as loud noises (noises made by me around the house), has increased again, where by nightfall, my brain feels bruised or inflamed (hard to describe it) always around the left hemisphere. And my foot and calf feel tingly and overly hot. Also, the branch of the trigeminal-maxillary nerve on my left cheek and under the eye feels like it may begin spasming again (which had been settled after 12 months). In addition, I seem to be experiencing a return of the menthol sensory feeling on the skin, this time around the left side of my mouth.

The joint noises have not eased; the muscle spasming has increased. Now it seems to be happening in two places instead of randomly in one isolated muscle. I also need to mention I seem to have picked up some infection around my private part. The skin on the head of my penis was peeling from the tip, which led me to believe something was coming from the urine, like a fungus. There was no discharge. I have not had a sexual partner for over 17 months (since my fiancé left due to her inability to cope with my illness), and I wash regularly. I bought some Daktarin powder (Miconazole Nitrate) which cleared the skin problem quickly. But I am unsure about bladder 'picking' pains, so I urinated into a plastic bottle last night, and upon closer inspection, it is full of white growth (I have attached the pictures for your reference). Maybe yeast? It seems to have settled in a thick cloud at the bottom of the bottle now hours later. Is it possible that Prednisolone has suppressed the immune system, and maybe these things are less controlled than usual? Should I take any medication for this or let it go away naturally?

Wondering about your overall thoughts on it. Will I complete the course of Prednisolone, or do you think it might be doing more harm than good? Or maybe my immune system and the overall system will benefit from the rebound after I finish the course.

Kindly give your suggestions.

Hi doctor,

Thank you for your reply.

I will try to have the urine CE test carried out to find out what this problem is, I do not know if it is related, but I have been urinating about 1.5 liters every night. With the tablet Prednisolone, do you want me to alter the regimen, stay on 10 mg a day (5 mg in the morning and again in the evening?) now for 15 days, and then 5 mg for 15 days? Do you feel the Prednisolone requires longer to have a beneficial effect? Can you share more information on what might be happening?

Maybe I will review the anxiolytics use as you suggest. Should I get a CBC completed to establish whether the Prednisolone is affecting white blood cells? I could have the hormone profile clarified at the same time as that. I have been thinking a lot today about the chance another vaccine might correct my messed up the immune system. I cannot help but wonder whether it is 'stuck' on the wrong instruction or something. I remember when I went for the TB test the day after my lingering COVID cough began to clear, and then, a week later, it was gone. I believe it stimulated my immune system into action. I am not sure. I just had my Ayurvedic medicine Septilin delivered. Also, it is supposed to help with joint noise when combined with a tablet of Diclofenac. But I will need to wait until I have finished the Prednisolone to start. They cannot be taken together, right?

Please help.

Hello doctor,

Thank you for your reply.

I have gone back to work, although my symptoms have not changed. I wanted to report back to you after your recommendations and see if you have any more ideas. So I tried the course of the tablet Prednisolone as described, with no changes in symptoms. I picked up a cold or flu which made me feel pretty terrible for about 1 to 2 weeks (persistent wheezy coughing with a bad headache every time I coughed). During that time, I noticed some improvements in muscle spasms. I developed a dry wheezy cough with no phlegm, which responded quite quickly to Benylin dry cough syrup. I also did the urine test, which showed as normal. However, at that stage, the problem had been gone for about a week and seemed to have been eradicated by Daktarin powder and time.

I also attempted to return to HBOT (hyperbaric oxygen therapy), which was a complete failure. It had dramatically reduced my tinnitus when I tried it nine months back, but this time, it worsened my patulous eustachian tube (left). I also experienced dry and itchy skin for a day or two afterward. I have had dry, eczema-type skin on my cheeks and forehead for the past few weeks. I notice these have improved over the past week or so. I also notice my back pain has nearly vanished over the past week. I cannot explain it much, and I did start taking Diclofenac 75 mg and Septilin three times a day. Maybe this has made a difference, and I do not know.

You may be interested in my latest blood results, taken about 11 days after stopping the Prednisolone. The neutrophils have increased a little bit, but the lymphocytes have decreased. I am guessing the high IgM value and CRP might represent the cold or flu I probably had at the time, although I feel I was over it or at the very end of it when these blood tests were taken. It is the first time my CRP values were detectable in 21 months since the injury. No abnormality was detected on the pituitary gland on the MRI head, which was one week before this, so I do not know how to interpret the continually high prolactin value (now at least 14 months). All thyroid measurements are normal, including anti-thyroid-related antibodies. That leaves the high IgE value, which has again been high for at least 14 months (when it was first captured but probably higher since the injury two years ago).

I am trying the Septilin for another week (2 weeks total), then will stop for a week, then I will try peptide therapy with thymosin alpha 1, which supposedly raises the production of T-cells. As I type, my right hand is getting weak and like the beginning of pins and needles, but not. I woke this morning with my left calf and foot similar to about 2/10 pins and needles type feeling. And my left upper cheek is a little painful, and has had an icy feeling on it all day today, similar to a small space on my right outer thigh, and I seem to be again waking with my right arm shuddering, although not as bad as it had been. I suspect the Septilin might aggravate the immune system, and these symptoms are flaring again. I noticed it a little when I first took Septilin. Maybe I should stop it. I have also started to wear a cervical collar which prevents me from turning my neck or moving my head to look down, which seems to make the nerve in my face feel sore. I should also mention I am now starting to experience some iciness around my left lower chin and upper lip.

So the picture is as muddy as ever. I would be grateful if you have any more suggestions or explanations as to what might be happening. Could it be that when my immune system is 'activated' to fight an infection, my symptoms improve but then come back when I have overcome that infection that my immune system's usual defenses are not as alert as usual? I think this has been called 'antibody-dependent enhancement.' Could the high IgE be explained by something foreign being in my body? Like a form of metal or another ingredient they used? A spiral CT is the only way to test for something like that. Anyway, I am out of ideas.

Please give your suggestions.

Hi doctor,

Thank you for your reply.

I hope you are right, although the blood report has not changed. Is there a chance the IgM level is chronic and might represent a different process? I know it can be associated with COVID's common variable, immunodeficiency, which we discussed before. It has been between 2.6 and 2.3 g/L for the last two years, staying around the threshold. That cannot be normal. I am not sure about the vitamin B12 levels, I tried receiving it via IV a few times a week, and the neuropathy or symptoms did not change. So the IgE might be related to my home, where I spend a lot of time. Maybe mold or something? What antihistamines should I take? It seems to have gone up quite a bit, from 244k UA/L a year ago to 497k UA/L. That is quite a jump. Is there anything else that could be causing it?

The prolactin was 388 mU/L last year and is now 330 mU/L. Do you think I should try a short course on Cabergoline? I have the tablet Dostinex. It is a complex picture, but I hope you have some idea. I should probably see an immunologist, but I do not know how to see one. I could use some advice on the immunoglobulin problem and disturbed NK profile.

Please give your suggestions.

Hi doctor,

Thank you for your reply.

The prolactin reference range is 86 to 325 ng/mL.

Thank you.

Hello doctor,

Thank you for your reply.

I wanted to update you and also see if you can offer any thoughts. You will recall I had been healthy until the vaccination over two years ago and had very little help from most doctors I had seen. Unfortunately, no treatments have been effective to date and I am still struggling. My main symptoms are:

1. Pins and needles in right hand and arm (sensory neuropathy).
2. Waking with pulsing or tremoring in my right arm and to a lesser extent in my left arm.
3. Debilitating tinnitus.
4. Eustachian tube dysfunction and joint or ligament noise in the neck, spine, and chest.
5. Left face swelling.
6. Chronic orchitis of the left testicle.
7. Chronic rhinitis or sinusitis.
8. Chronic dermatitis rash all over my face.
9. Right-hand finger and knuckle pain.
10. Lower back extreme stiffness if standing or kneeling still.
11. Neutropenia.
12. Strange 'icy' stabbing or picking feeling under the left eye and right outer thigh.
13. Random muscle spasming.
14. Left calf and foot 'weakness' and warmth.
15. Left cervical spine pain and often radiating headache.

As you know, I have tried a lot of treatments, have spent all I have, and unfortunately lost my career and relationships. I am now at the point where I am turning to more serious treatments. I liaised with a specialist immunology group that found very high levels of scd40l and Veg F as well as inflammatory cytokines. I have attached those results. They tried me on Maraviroc and Pravastatin, but unfortunately, I reacted badly to the drugs with the orchitis and tinnitus flare, so had to stop. It was very disappointing.

I think the time has come to do IVIG (intravenous immune globulin). Someone mentioned trying Sofosbuvir which may also be an option. But as far as I can see, I now need to self-administer human normal immunoglobulin; either through an infusion drip or subcutaneously. I have also considered trying a shot of Intaglob or Bharglob intramuscular, they would obviously be much easier to administer but would be a tiny dose in comparison to full IVIG treatment. Obviously, I would be extremely careful, administering a small amount on day one, and reviewing it each day over a five-day administration. I will either do half my body weight (0.5 gm/kg) or full (1 gm/kg). Research is not 100 % clear on the mechanism of action of introducing exogenous immunoglobulin, I think it might slowly work to get rid of troublesome antibodies because the system culls all of them to a normal level, other people with these symptoms after vaccination have had improvement, so it must be doing something positive.

People reported some success with Sofosbuvir after three to four weeks of use, research says it restores neutrophilic function. So I am not sure what my strategy should be. I also have two Filgrastim injections left which I never used, Clopidogrel, and Methylprednisolone. A friend can bring me the medications from abroad. I will prepare by getting fresh blood tests of all vitals. I understand that IVIG is risky. I never thought I would ever be in this position but seems the most thorough of all and the best chance to overcome whatever this thing is. Like everyone else with these problems, we all pray the changes to our cells are not permanent. I just want my life back.

Thank you.

Hello doctor,

Thank you for your reply.

I appreciate your valued response as always. To be honest, Pregabalin scares me, because of having worked with so many patients taking it and the side effects are not good. If it is one thing I have learned with this illness, I seem to react to everything. If a drug has side effects, I will get them. I did do vitamin B12 IV a year ago weekly and took supplements for a while, but no changes, unfortunately. With the Levocetirizine, I can get Xyzal here in 5 mg. I will try it at night, previously I tried H1 and H2 blockers for 10 days with limited success.

The thing is it has been over two years and those inflammatory cytokine levels are still very high. The VEGF and SCD (sickle cell disease) 40L are worrying. Could they be a result of anything else? Most of the people still suffering after vaccination have tried a lot of big treatments, but they always relapse, some doctors say the vaccination has made changes at a cellular level, meaning our cells are continually producing spike protein, which as you know means continual problems. I have been doing all sorts of anti-inflammatory supplements and therapies for over two years.

Could there be a chance that I have not produced adequate antibodies to the spike protein? Clearly, my immune system is seriously affected in that I have developed neutropenia (albeit mild) but increasing neutrophils did not change anything. Could there be a chance that injecting a small amount of human normal immunoglobulin, such as 0.5 % 10 ml (500 mg mostly IgG) might provide appropriate antibodies to relieve my system and allow it to normalize? What would be the consequences? I think it is worth trying. Greatly appreciate what you think about that.

Thank you.