What are the complications of ankylosing spondylitis?

Question

Hello doctor,

My aunt, who is 56 years old, has been dealing with ankylosing spondylitis for the past two years. She is taking Methotrexate and other pain relievers too. However, her symptoms remain uncontrolled. If she misses even one day's medication, her pain shoots up.

What could be the reason for her uncontrolled symptoms? What are the complications of ankylosing spondylitis that she should be aware of? Will she face any side effects of taking too many medicines? Are there any new advancements in treating or managing ankylosing spondylitis?

Please help.

Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

I read your query and can understand your concern.

This lack of control may occur due to factors such as severe inflammation, delayed response to treatment, or other underlying conditions.

Ankylosing spondylitis (AS, a type of arthritis that affects the spine, leading to inflammation and potential fusion of the vertebrae) can lead to complications such as spinal fusion, which restricts movement; eye issues like iritis (inflammation of the iris, the colored part of the eye) or uveitis (inflammation of the uvea, the middle layer of the eye); heart issues; lung problems; and osteoporosis (a condition in which bones become weak and brittle).

For your information, every allopathic medication (traditional medications used to treat disease, as opposed to alternative therapies) has potential side effects such as liver problems, stomach upset, and kidney issues. If your aunt faces any side effects, it may be necessary to consider changing her medications.

For better control of symptoms, her doctor may consider recent advancements in AS management, including newer biologics (medications derived from living organisms that target specific parts of the immune system) and Janus kinase (JAK) inhibitors (a class of medications that block specific enzymes involved in the immune response). Physical therapy and lifestyle modifications, such as mild exercises are also beneficial and help maintain mobility.

I hope I have answered your question.

Let me know if I can assist you further.

Thank you.