Antiphospholipid Syndrome

Antiphospholipid syndrome is a condition where the body's immune system creates antibodies to make the blood to form a clot. It causes dangerous effects in the body by forming clots in the lungs, kidneys, heart, brain, and legs. In pregnant women, antiphospholipid syndrome causes miscarriages. There is no medication to cure it, and medications only reduce the formation of blood clots.

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What tests should I do for APS syndrome?

Query: Hello doctor, Following my previous query regarding APS syndrome with immunological features of lupus, I am attaching my latest blood test results. After starting the Plaquenil, my polyarthralgia is less painful than 12 to 18 months ago. Although somewhat slow, the decrease in pain is evident. A...  Read Full »

Dr. Nupoor Acharya

Answer: Hello, Welcome to Good to know that your symptoms are improving. All your test results look normal (attachments removed to protect the patient’s identity). It would be best if you continued getting these tests at regular intervals, as it will help in the early identification...  Read Full »

What causes recurrent miscarriages?

Query: Hi doctor, At first, I ended up with miscarriage in 8 months. It was a natural one when the baby movement got less and I was unable to determine. Then, after eight months I conceived. That also ended with a miscarriage in a month's time. I have gone through D and C. Now, I have been trying to conce...  Read Full »

Dr. Dattaprasad Balasaheb Inamdar

Answer: Hi, Welcome to Three months is a short duration for conception to occur. Chance of pregnancy after trying for six months is 70%. You can safely try naturally for another six months. There is very less likely to be any pathology preventing pregnancy. If conception does not occur in anoth...  Read Full »

Can Azathioprine cause heart pain in catastrophic antiphospholipid syndrome patients?

Query: Hello doctor, I have been diagnosed with catastrophic antiphospholipid syndrome before three years and had a brain stroke in the same month due to blood clots. Since then I have not encountered any blood clot and have been on Acitrom 5 mg, Ecosprin 75 mg and Azathioprine 100 mg. Three weeks back ne...  Read Full »

Dr. Prakashkumar P Bhatt

Answer: Hello, Welcome to What treatment did you get during Catastrophic antiphospholipid syndrome? Was your APLA, LA test was positive? Azoran is an immunomodulatory drug and has some role in APLA syndrome. HCQS is a good drug for APLA as it has an anti-inflammatory plus anticoagulant effe...  Read Full »

Does raised dRVVT suggest that I am LA positive?

Query: Hello doctor, I was recently diagnosed with a blood clot in my left jugular vein and put on Eliquis (10 mg twice daily for a week, now 5 mg twice daily). I was also recently diagnosed with some sort of autoimmune disorder, but it is not clear yet which one. After being diagnosed with the blood clot...  Read Full »

Dr. Parth R Goswami

Answer: Hi, Welcome to If you have antiphospholipid antibody syndrome(APS) then your anti-cardiolipin antibody or lupus anticoagulant should be positive. Additionally in APS, the raised RVT (renal vein thrombosis) is not corrected by adding normal plasma. So lupus or APS chance seems to be le...  Read Full »

What is the effect of stopping Pradaxa?

Query: Hello doctor, My wife just started on Pradaxa (blood thinner) a week back. She has an antiphospholipid antibody, but she has not had any clot before. We started seeing a couple of small bruises today in her hand without any injury. I want to know if we need to stop it. We consulted a doctor in the ...  Read Full »

Dr. Sadaf Mustafa

Answer: Hello, Welcome to How was she diagnosed with APS (antiphospholipid antibody syndrome)? She most likely has an incidental APS, and I doubt if there are any recommendations to use anticoagulation in this particular group (positive antibodies with no clots). Now coming to your question...  Read Full »

How to confirm the reason for my abortion?

Query: Hi doctor, I had some hormonal imbalance problem. I had my last periods two months back. I became pregnant and took an hCG test. It was 121 and I took viability scan at 7.6 weeks. The heart rate was 92 bpm, which is less compared to one week. So, doctor suggested me to repeat a scan after two weeks....  Read Full »

Dr. Bharat Patodiya

Answer: Hello, Welcome to Your ovarian reserve appears to be good. Recurrent abortion needs evaluation for the following. Parental karyotype abnormality, uterine abnormalities, antiphospholipid syndrome, immunologic dysfunction, thyroid dysfunction, diabetes mellitus, polycystic ovary ...  Read Full »

Will vitamin D deficiency during pregnancy affect baby growth?

Query: Hi doctor, My wife is 29 years old and we have a 5 year old son. It was a premature delivery in the 34th week and it was a normal delivery. After that, she had three abortions and all are because of no fetal growth and heartbeat. Currently, she is 10 weeks pregnant. Her recent ultrasound scan sho...  Read Full »

Dr. Sonal Prasad

Answer: Hello, Welcome to The vitamin D levels are in deficient range and vitamin B12 levels are normal. There is no need to discontinue the pregnancy due to these values. Vitamin D supplementation will help to have adequate levels in baby. I suggest vitamin D supplementation Calcirol sachet 60...  Read Full »

What causes extreme swelling and pain in both legs?

Query: Hi doctor, I have extreme swelling and pain in both lower legs and feet. I also have severe pain in both hands, on all fingers, both wrists, both forearms,both elbows as well as both knees. It is extremely painful for me to stand and walk. I had a CMP (comprehensive metabolic panel) and CBC done...  Read Full »

Dr. Naval Mendiratta

Answer: Hello, Welcome to I have gone through your history and the blood reports (attachments removed to protect patient identity) along with the photographs you have posted. Well, there is gross swelling in both your legs. But, the albumin levels are not so low to explain the edema. Even urine...  Read Full »

I am being tested for antiphospholipid syndrome. What will the treatment be?

Query: Hi doctor, Following a DVT, my hematologist sent me for a blood test and it needs to be repeated again. According to the test request form, the request is 'antiphospholipid ab blood' and clinical details are 'previous VTEs, lupus ab positive as of October last year'. I am keen to understand the im...  Read Full »

Dr. Singh Smrita

Answer: Hello, Welcome to Systemic lupus erythematosus (SLE) is an autoimmune condition. The condition can affect a single organ or multiple organ systems. DVT (deep vein thrombosis) in SLE is multifactorial. The most common cause is the presence of antiphospholipid antibodies. However, in s...  Read Full »

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