Q. Is there any new medicine for anxiety as SSRI not helping me?

Answered by
Dr. Parth N. Nagda
and medically reviewed by Dr. Vinodhini. J
This is a premium question & answer published on Feb 29, 2020 and last reviewed on: Mar 02, 2020

Hello doctor,

I cannot get any SSRI medicine to work anymore after 25 years. I have anxiety only from morning to mid-afternoon. Doctor put me on Oxcarbazepine 300 mg daily for anxiety but this seizure medicine is making me dizzy and very tired and off-balance. My head feels weird. I just weaned completely off Zoloft three days ago.

What new family of medicines do you suggest for me to try for my anxiety? Lately, I can get it under control for four to five hours taking 1/4th of a 0.25 mg of Xanax. I take a Sliver tablet of 0.25 mg three to four times a day or maybe once. Anxiety ends every day at around 3-4 PM each day and I sleep fine too.



Welcome to

Considering your age, it will be difficult to try a low dose of TCA (tricyclic antidepressant), but if nothing works that is always an option. Apart from an SSRI (selective serotonin reuptake inhibitors), there is always SNRI (serotonin-norepinephrine reuptake inhibitor) like Venlafaxine which is pretty effective for anxiety.

Also instead of Oxcarbazepine, you could try a low dose of may be 200 mg of Sodium valproate. Also, there are some dietary supplements like L-Theanine 200 mg which can be taken two times a day or on SOS basis.

Finally, instead of Xanax (Alprazolam), you can try Tofisopam which is a different type of benzodiazepine with lesser addictive potential, no sedation or impairment in work performance.

Also, consider doing deep breathing exercises daily and when you have an anxiety attack do more repetitions of deep breathing. Also, consider starting with yoga, meditation, progressive muscle relaxation or other types of calming exercises.

Was this answer helpful?


Same symptoms doesn’t mean you have the same problem. Consult a doctor now!

Related Questions:
Having depression and not getting well with SSRI. Can you suggest any treatment?

Hi doctor, I am suffering from depression, anxiety, and OCD ... Please suggest me the treatment for depression ...   Read full

Will my anxiety relapse if I stop SSRI?

Initially, I was prescribed Paxil 20 mg, which helped treat my anxiety and depression but I started having side effects of weight gain, fatigue, and sexual dysfunction ...   Read full

Can Xanax cause depression, insomnia, and anxiety?

I have started trying to stop, or take less, and have noticed feelings of depression, insomnia, feeling anxious, and an aching neck and jaw and feeling tense ...   Read full

Also Read Answers From:

ideaComprehensive Medical Second Opinion.Submit your Case

Also Read

Coronavirus Variant Arcturus: | Omicron XBB.1.16 Variant
Arcturus is an emerging variant of the Omicron virus that causes various symptoms and spreads rapidly across the world. ...  Read more»
Adrenaline Rush - Symptoms, Causes, Effects, and How to Control
Adrenaline is a hormone responsible for fight or flight response. It is also a neurotransmitter and medicine. It is also...  Read more»
Fatty Liver - Types, Symptoms, Stages, and Treatment
The liver is the largest gland in the body. Its primary function is to process the food and drinks we consume. and filte...  Read more»

Ask your health query to a doctor online?

Ask a Psychiatrist Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.