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How to differentiate benign and malignant adrenal node?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I recently underwent a routine CT scan without contrast, which revealed a 2.8 adrenal node with a measurement of 41 HU. I want to clarify whether I have a history of cancer as I am currently experiencing no symptoms. The rest of the pelvic abdominal scan results were within the normal range. I am aware that cancer occurrences in the adrenal gland are exceedingly uncommon, often stemming from metastases originating elsewhere in the body. Despite this knowledge, I find myself deeply concerned.

As part of the ongoing assessment, my healthcare provider has recommended blood and urine tests, along with a contrast CT scan. While I understand that a high HU reading can sometimes be associated with malignancies, I am curious if there are other potential explanations for this finding.

Please clarify.

Thank you.

Answered by Dr. Shaikh Sadaf

Education:

MBBS

Professional Bio:

Dr. Shaikh Sadaf is a Specialist in Diabetology and Endocrinology dedicated to providing comprehensive care for patients with hormonal and metabolic disorders. With two decades of clinical experience, she is skilled in managing diabetes, thyroid conditions, and a wide range of endocrine issues. Having trained internationally and earned prestigious memberships from leading medical colleges, Dr. Sadaf combines global expertise with a compassionate, patient-centered approach. She focuses on personalized treatment, preventive care, and long-term wellness to help patients achieve better health outcomes.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome to icliniq.com.

I read your query and I can understand your concern.

I would suggest considering an MRI (magnetic resonance imaging) of the adrenal gland, which could provide clear insights to determine the nature of the condition – whether it is benign or not. It is crucial to note that adrenal incidentalomas measuring less than 1.57 inches should be monitored over time. In cases where the size exceeds 1.57 inches, and the Hounsfield Units (HU) measurement is greater than 10, along with irregular borders, then there could be a possibility of malignancy.

For a more accurate confirmation, it is essential to examine the results of the blood tests as well. While there seems to be a suspicion of adenoma, making a definitive assessment without an MRI scan is challenging.

I understand that this information might be concerning, and I apologize for the unsettling news. However, a more comprehensive evaluation is necessary to move forward. Further assessment will provide a clear understanding of the situation.

I hope this helps.

Thank you.

Patient's Query

Hello doctor,

Thank you for the reply.

My doctor had suggested that I do blood tests first but she thinks that it is most likely a benign adenoma and the chance of malignancy is unlikely.

Answered by Dr. Shaikh Sadaf

Education:

MBBS

Professional Bio:

Dr. Shaikh Sadaf is a Specialist in Diabetology and Endocrinology dedicated to providing comprehensive care for patients with hormonal and metabolic disorders. With two decades of clinical experience, she is skilled in managing diabetes, thyroid conditions, and a wide range of endocrine issues. Having trained internationally and earned prestigious memberships from leading medical colleges, Dr. Sadaf combines global expertise with a compassionate, patient-centered approach. She focuses on personalized treatment, preventive care, and long-term wellness to help patients achieve better health outcomes.

This doctor is not available for online consultations on the platform anymore.

Hi,

Welcome back to icliniq.com.

Glad to have you back.

I am optimistic that the results will indeed show a benign adenoma, as the characteristics observed so far are not strongly indicative of malignancy.

I wish you good health.

Thank you.

Patient's Query

Hi doctor,

Most of the tests came out normal except for a few that were borderline. I was not asked to restrict any food or caffeine before the test. I have absolutely no symptoms. I am under a lot of stress as my body is trying to recover from a spinal cord contusion. What would be the next steps to manage this conservatively?

Answered by Dr. Shaikh Sadaf

Education:

MBBS

Professional Bio:

Dr. Shaikh Sadaf is a Specialist in Diabetology and Endocrinology dedicated to providing comprehensive care for patients with hormonal and metabolic disorders. With two decades of clinical experience, she is skilled in managing diabetes, thyroid conditions, and a wide range of endocrine issues. Having trained internationally and earned prestigious memberships from leading medical colleges, Dr. Sadaf combines global expertise with a compassionate, patient-centered approach. She focuses on personalized treatment, preventive care, and long-term wellness to help patients achieve better health outcomes.

This doctor is not available for online consultations on the platform anymore.

Hi,

Welcome back to icliniq.com.

I just went through your reports (attachments removed to protect the patient's identity), and they are fairly acceptable and do not seem to be a cause for concern. I do not understand why there was xxxxxx on metanephrines and normetanephrines. I was also hoping to see an MRI of the adrenal gland as well. I feel sorry to hear about your injury. I hope physiotherapy will be helpful in such cases. Nothing else needs to be done at the moment. You would require a regular follow-up scan.

I hope this helps. Do get back if you have any further queries.

Thank you.

Patient's Query

Hello doctor,

Thank you for the reply.

Yes, physiotherapy has helped but I have mainly nerve damage (tingly, numbness) and a really tight tone (spasticity) following the C6 contusion. I was struck by a car nine months back while crossing the street. I hope for more recovery as it has been only nine months. I was told that it would take 12-24 months to recover but it had been extremely stressful and challenging. I am trying not to lose hope.

The doctor incidentally found the adrenal node while viewing the CT scan after my accident. My doctor said that he would refer my reports to an endocrinologist. Thank you for your opinion. I do not think I could undergo any more tests or procedures right now since the anxiety over this makes my neuropathy much worse.

Thank you.

Answered by Dr. Shaikh Sadaf

Education:

MBBS

Professional Bio:

Dr. Shaikh Sadaf is a Specialist in Diabetology and Endocrinology dedicated to providing comprehensive care for patients with hormonal and metabolic disorders. With two decades of clinical experience, she is skilled in managing diabetes, thyroid conditions, and a wide range of endocrine issues. Having trained internationally and earned prestigious memberships from leading medical colleges, Dr. Sadaf combines global expertise with a compassionate, patient-centered approach. She focuses on personalized treatment, preventive care, and long-term wellness to help patients achieve better health outcomes.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome back to icliniq.com.

I am very sorry for your symptoms, but I suggest you take Baclofen 10 mg thrice daily for spasticity provided you do not have any contraindications like pregnancy or allergy. Yes, you can just wait and have a yearly checkup yearly for your adenoma.

I hope you feel better soon.

thank you.

Patient's Query

Hello doctor,

I hate to bother you again but I just want to be clear. My 24-hour metanepherine is 575 nmol/L which is higher than the standard 399 nmol/L and the cortisol level is 1.8 mcg/dL which is slightly higher than the cutoff value of 1.7 mcg/dL. Is this still acceptable? Also, yes I am on tablet Baclofen and it is the only medicine that I take for my symptoms.

Answered by Dr. Shaikh Sadaf

Education:

MBBS

Professional Bio:

Dr. Shaikh Sadaf is a Specialist in Diabetology and Endocrinology dedicated to providing comprehensive care for patients with hormonal and metabolic disorders. With two decades of clinical experience, she is skilled in managing diabetes, thyroid conditions, and a wide range of endocrine issues. Having trained internationally and earned prestigious memberships from leading medical colleges, Dr. Sadaf combines global expertise with a compassionate, patient-centered approach. She focuses on personalized treatment, preventive care, and long-term wellness to help patients achieve better health outcomes.

This doctor is not available for online consultations on the platform anymore.

Hi,

Welcome back to icliniq.com.

I did mention in my reply above that the metanephrines value was xxxxxx and I could not understand why it was hidden for me. Yes, it is high and it suggests pheochromocytoma if the value is high. In such cases, your blood pressure should be closely monitored. So, this could explain the adrenal adenoma as pheochromocytoma is a tumor that arises from the adrenal gland. The definitive treatment involves blood pressure monitoring and surgical excision of the tumor. Your cortisol levels are acceptable.

I wish you good health.

Thank you.

Patient's Query

Hello doctor,

Thank you for the reply.

Would they always have to remove it, or could they retest or monitor? Is not this a very rare tumor?

Answered by Dr. Shaikh Sadaf

Education:

MBBS

Professional Bio:

Dr. Shaikh Sadaf is a Specialist in Diabetology and Endocrinology dedicated to providing comprehensive care for patients with hormonal and metabolic disorders. With two decades of clinical experience, she is skilled in managing diabetes, thyroid conditions, and a wide range of endocrine issues. Having trained internationally and earned prestigious memberships from leading medical colleges, Dr. Sadaf combines global expertise with a compassionate, patient-centered approach. She focuses on personalized treatment, preventive care, and long-term wellness to help patients achieve better health outcomes.

This doctor is not available for online consultations on the platform anymore.

Hi,

Welcome back to icliniq.com.

Yes, it is a very rare tumor. It appears from your metanephrine result interpretation that it could be a pheochromocytoma. Of course, an MRI of the adrenal gland is required for a definitive diagnosis. Yes, it has to be removed once it is confirmed. The clinical symptoms need to be assessed by the clinicians who examine you as well.

I have only mentioned the likelihood as indicated by the raised metanephrines and the CT (computed tomography) scan reports. It has to be confirmed by MRI and clinical examination and thorough history.

I wish you good health.

Thank you.

Medically reviewed by iCliniq medical review team
Published At November 11, 2023
Reviewed At June 26, 2024

Education:

MBBS

Professional Bio:

Dr. Shaikh Sadaf is a Specialist in Diabetology and Endocrinology dedicated to providing comprehensive care for patients with hormonal and metabolic disorders. With two decades of clinical experience, she is skilled in managing diabetes, thyroid conditions, and a wide range of endocrine issues. Having trained internationally and earned prestigious memberships from leading medical colleges, Dr. Sadaf combines global expertise with a compassionate, patient-centered approach. She focuses on personalized treatment, preventive care, and long-term wellness to help patients achieve better health outcomes.

This doctor is not available for online consultations on the platform anymore.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Education:

MBBS

Professional Bio:

Dr. Shaikh Sadaf is a Specialist in Diabetology and Endocrinology dedicated to providing comprehensive care for patients with hormonal and metabolic disorders. With two decades of clinical experience, she is skilled in managing diabetes, thyroid conditions, and a wide range of endocrine issues. Having trained internationally and earned prestigious memberships from leading medical colleges, Dr. Sadaf combines global expertise with a compassionate, patient-centered approach. She focuses on personalized treatment, preventive care, and long-term wellness to help patients achieve better health outcomes.

This doctor is not available for online consultations on the platform anymore.

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