Human brain transplant or full body transplant is possible theoretically. Research is going on in this field where we have a case of head transplant from one dog to another where the dog died after a few days. There are a few reports of surgeons who believe it can be a reality in humans in 2 years.
The most significant barrier in head transplant is the inability of the nerves to regenerate fully. A scarred nerve will not be able to transmit signals properly. Let us hope it would be possible someday and that would be a great achievement for humanity.
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