ADVERTISEMENT

Q. Is Mitomycin C necessary for urinary bladder cancer?

Answered by
Dr. Ajit Naniksingh Kukreja
and medically reviewed by Dr. Sneha Kannan
This is a premium question & answer published on Dec 24, 2015 and last reviewed on: Mar 11, 2019

Hi doctor,

My elder brother has undergone removal of low grade papillary carcinoma of urinary bladder without any local lymphatic involvement. He was advised to take Mitomycin C after six weeks of surgical intervention TURBT. Is it necessary to go for the drug? Is it prophylactic or therapeutic? I need your valuable opinion at the earliest.

ADVERTISEMENT
#

Hi,

Welcome to icliniq.com.

Superficial bladder cancer or nonmuscle invasive bladder cancer includes carcinoma in situ (CIS or Tis), Ta tumors, and T1 tumors.

These are all cancers that have been found very early in their development. The cancer cells are only in the lining of the innermost layer of the bladder.

These type of tumors have more than five-year survival rate, but the recurrence is an issue.

Multiple trials have shown intravesical instillation of BCG (Bacillus Calmette-Guerin) or Mitomycin C (MMC). This has shown progression in 7.67% of the BCG subjects and 9.44% of MMC subjects.

I would suggest you go for it. I have seen patients surviving for two decades after such therapy.

Hi doctor,

Thanks a lot for your opinion. My elder brother had pancreatic carcinoma about 15 years ago. He got partial resection of the pancreas, now having dilated pancreatic duct with stones. He has diabetes, which is under control now. His surgeon, who did the TURBT, advised intravesical installation of Mitomycin 60 mg weekly as chemoprophylaxis. His body weight is about 45 kg. Being a medical practitioner, he has a doubt whether the advised dose is necessary for chemoprophylaxis or a lower dose would be sufficient. I would be waiting for your valuable opinion.

#

Hi,

Welcome back to icliniq.com.

Yes, the prescribed dose is adequate and he should go for it. Clinical trials have demonstrated the benefit of the same.

Hi doctor,

My elder brother completed six doses of Mycomycin 60 mg weekly as chemoprophylaxis. After 15 days of completion of the therapy there was sudden onset of hematuria. Ultrasound shows polypoid mucosal thickenings at the posterosuperior aspect of the urinary bladder. Would you give your opinion on what he should do now?

#

Hi,

Welcome back to icliniq.com.

I have gone through the reports (attachment removed to protect patient identity).

Polypoid mucosal thickening at the posterosuperior aspect of the urinary bladder could be due to reactionary inflammation of the mucosa. We have seen a similar effect with intravesical BCG.

I would suggest you get a urine culture and if needed repeat the USG after a week or so to see the regression in inflammation. Get back to me with the reports once done.


Was this answer helpful?

 | 

Same symptoms doesn’t mean you have the same problem. Consult a doctor now!



Related Questions:
Leptospirosis, a Bacterial Disease - Things You Need to Know

.. zoonotic disease, which is common in the post-monsoon season. If no timely intervention is provided, then it can endanger life .. ...   Read full

Does a pancreatic growth with nephrotic syndrome indicate malignancy?

I have no symptoms of pancreatic cancer ... However, a paternal great grandmother died of pancreatic cancer in her 60s ...   Read full

Pterygium (Surfer's eye) - causes, prevention and treatment options

Recurrence Prevention Measures : In view of the high recurrence rate of bare sclera technique, various adjunctive measures as medical methods, beta-irradiation, and surgical methods have been ad...   Read full

Also Read Answers From:

ideaComprehensive Medical Second Opinion.Submit your Case

Also Read


Dengue Fever: Common Questions Answered
Dengue fever is a self-limiting mosquito-borne viral illness that has taken a massive toll on public health. Read below ...  Read more»
Listeriosis - Causes, Symptoms, Diagnosis, Treatment, and Prevention
Listeriosis is a bacterial infection, that can result in severe complications like meningitis, sepsis, and even death. R...  Read more»
Myositis - Types, Symptoms, Causes, Treatment, and Prognosis
The term "myositis" refers to a set of uncommon diseases. To know more about myositis, read the full article below.  Read more»

Ask your health query to a doctor online?

Ask a Surgical Oncologist Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.