Clomipramine

Clomipramine is used to treat obsessive-compulsive disorder (OCD), panic disorder, major depressive disorder, and chronic pain. It belongs to a group of drugs called tricyclic antidepressant (TCA). Sleepiness, weight gain, sexual dysfunction, and constipation are common side effects.

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Did my OCD and anxiety worsen because I switched over from the tablet Escitalopram to Clomipramine?

Query: Hello doctor, My anxiety increased after I switched over from the tablet Escitalopram to Clomipramine. I have been taking Clomipramine tablets for two weeks, and my obsessive-compulsive disorder (OCD) has worsened. Currently, I am taking tablets Anafranil 150 mg and Amisulpride 150 mg. Did my OCD wo...  Read Full »


Dr. Vishal Anilkumar Gandhi

Answer: Hello, Welcome to icliniq.com. I can understand your situation. However, I humbly request that once you are stable on some specific medication, you must not change them because it is difficult to switch to another medicine and get stable. Sometimes you might take a few weeks to get stable. So, I s...  Read Full »

Can OCD cause repeated image popping in mind?

Query: Hi doctor, I am a 25 year old male. I am scared of turning into a gay or homosexual. In the past, I had senseless and intrusive images popping in my head that I am kissing a guy whenever I used to be with my male friends. I never felt an attraction towards any guy. It happened six years before, but ...  Read Full »


Dr. Saraswat Kumarshri Shriniwas

Answer: Hello, Welcome to icliniq.com. After analyzing your current complaint and taking into consideration your previous history, I am of the opinion that your current symptom is also a symptom of Obsessive compulsive disorder (OCD). An obsession is an automatic, repetitive, intrusive and senseless thou...  Read Full »

How to overcome my strange anxiety?

Query: Hi doctor, I have a strange anxiety that something will happen to my loved ones whenever they go out. What shall I do?  Read Full »


Dr. Padmapriya Chandran

Answer: Hi, Welcome to icliniq.com. You seem to be harboring recurrent intrusive thoughts of harm befalling your loved ones. These thoughts can cause guilt even though you know that they are irrational. However, you might try to control these thoughts. It will be of no use. The symptoms that you have de...  Read Full »

Please suggest alternate medication for Clomipramine.

Query: Hi doctor, I started taking Clofranil 25 mg at the sleeping time for having useless thoughts with disturbed sleep. After few years, I started hearing whistling sounds and so I started taking Seizunil 200 mg with Clofranil 25 mg and Alp 0.5 mg. Now it has been five years. I want to stop taking Clofr...  Read Full »


Dr. Vishal Anilkumar Gandhi

Answer: Hi, Welcome to icliniq.com. If you want to stop your medication, then you need to taper off. Do not stop it abruptly. It gives you withdrawal symptoms. You should take tablet Clofranil 10 mg (Clomipramine) daily for another four weeks and then start taking it on alternate days for another four...  Read Full »

How to prevent serotonin syndrome while taking antidepressants?

Query: Hi doctor, I am under treatment for OCD and anxiety symptoms. I have had very hard months with extreme anxiety, panic attacks and depersonalization. Now, I am on Duloxetine 60 mg (will stop in the next 7 weeks), Paroxetine 20 mg (will be reduced in the following weeks), Clomipramine hydrochloride...  Read Full »


Dr. Saraswat Kumarshri Shriniwas

Answer: Hi, Welcome to icliniq.com. There is always a possibility of serotonin syndrome when two or more serotonergic antidepressants are being used. However, Clomipramine and an SSRI (selective serotonin reuptake inhibitor) like Paroxetine are frequently used together in resistant OCD (obsessive-compulsive...  Read Full »

Why do I fear so many things?

Query: Hi doctor, I am a 46 year old male. My health is good since my childhood. I am a pure vegetarian. I do not smoke or drink alcohol. I have completed my PhD in plant biotechnology. My mother died when I was 10 due to heart problems. My father died a year back and he was healthy except minor hyperten...  Read Full »


Dr. Saraswat Kumarshri Shriniwas

Answer: Hello, Welcome to icliniq.com. I have gone through your detailed history. Your primary complaints are of multiple phobias, including agoraphobia. It is quite evident from other details that you are physically healthy and the problems are of psychological origin. Now, coming to your medicine history...  Read Full »

How to treat anxiety?

Query: Hi doctor, I am suffering from anxiety. Please help.  Read Full »


Dr. Saraswat Kumarshri Shriniwas

Answer: Hi, Welcome to icliniq.com. Your description of symptoms is concise and specific, which makes it easy to diagnose your condition. Mental illnesses are broadly classified into neurosis and psychosis. In neurosis, a person does not lose contact with reality and understands that he has a mental iss...  Read Full »

How can a person with OCD and an intense fear of sleep fall asleep?

Query: Hello doctor, I have been diagnosed with OCD. My OCD comes in the form of intense fear of sleep for the past five years, but it has gotten worse within the past couple of months. I am afraid the moment sleep comes, I fight this feeling until I am exhausted. How can I make peace with falling asleep a...  Read Full »


Dr. Aditya Gupta

Answer: Hello, Welcome to icliniq.com. I will start with the pharmacological part. You can discuss with your treating doctor regarding increasing the dose of Clomipramine, not only will it help with sleep but also in decreasing the obsessions. You can also discuss regarding substituting it with Fluvoxamin...  Read Full »

What is the recommended dose of Anafranil for OCD?

Query: Hello doctor, I am a 21-year-old male. I have OCD for past five years. I went to several doctors and used too many drugs such as Sertraline and Fluoxetine and Anafranil. The only drug that helped was Anafranil. I asked from my doctor to prescribe Anafranil but he denied and in every visit he prescr...  Read Full »


Dr. Vandana Patidar

Answer: Hello, Welcome to icliniq.com. Anafranil (Clomipramine) is a type of older antidepressants, and it has some undesirable side effects like constipation dryness of mouth, at times effect on the heart. Because of the side effect for file usually, doctors refrain from going for higher doses. But i...  Read Full »

Is it safe to use Clofranil during pregnancy?

Query: Hello doctor, I am planning for pregnancy aged about 36 years. But I am an OCD patient on a prescription of Clofranil 50 mg daily. So what are the risks involved, is it safe to use the medicine during pregnancy?  Read Full »


Dr. Deepthi

Answer: Hi, Welcome to iclinq.com. Clofranil (Clomipramine) should not be used in pregnancy. It is a category C drug that means if potential benefits justify the risk to the fetus, then you can use. As far as of now no well-controlled studies in humans, but it will not cause anomalies but it may affect yo...  Read Full »

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