Common "Clomipramine" queries answered by top doctors | iCliniq


Clomipramine is used to treat obsessive-compulsive disorder (OCD), panic disorder, major depressive disorder, and chronic pain. It belongs to a group of drugs called tricyclic antidepressant (TCA). Sleepiness, weight gain, sexual dysfunction, and constipation are common side effects.

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My OCD is getting worse day by day despite medicines. What to do?

Query: Hi doctor, I have been suffering from severe OCD for the last 12 years. Although medications helped improve my symptoms a lot, they still go beyond control occasionally. The current medications include tablet Daxid (300 mg per day) which suitably works for me to date. Other medicines prescribed from...  Read Full »

Dr. Vandana Patidar

Answer: Hello, Welcome to How much symptom control would you rate on a scale of 100? If tablet Daxid (Sertraline) helped you a lot, I suggest you continue taking it after consulting your specialist doctor and discussing it with him or her. Usually, OCD (obsessive-compulsive disorder) responds...  Read Full »

What is the recommended dose of Anafranil for OCD?

Query: Hello doctor, I am a 21-year-old male. I have OCD for past five years. I went to several doctors and used too many drugs such as Sertraline and Fluoxetine and Anafranil. The only drug that helped was Anafranil. I asked from my doctor to prescribe Anafranil but he denied and in every visit he prescri...  Read Full »

Dr. Vandana Patidar

Answer: Hello, Welcome to Anafranil (Clomipramine) is a type of older antidepressants, and it has some undesirable side effects like constipation dryness of mouth, at times effect on the heart. Because of the side effect for file usually, doctors refrain from going for higher doses. But if you ...  Read Full »

Did my OCD and anxiety worsen because I switched over from the tablet Escitalopram to Clomipramine?

Query: Hello doctor, My anxiety increased after I switched over from the tablet Escitalopram to Clomipramine. I have been taking Clomipramine tablets for two weeks, and my obsessive-compulsive disorder (OCD) has worsened. Currently, I am taking tablets Anafranil 150 mg and Amisulpride 150 mg. Did my OCD wo...  Read Full »

Dr. Vishal Anilkumar Gandhi

Answer: Hello, Welcome to I can understand your situation. However, I humbly request that once you are stable on some specific medication, you must not change them because it is difficult to switch to another medicine and get stable. Sometimes you might take a few weeks to get stable. So, I s...  Read Full »

Is it safe to use Clofranil during pregnancy?

Query: Hello doctor, I am planning for pregnancy aged about 36 years. But I am an OCD patient on a prescription of Clofranil 50 mg daily. So what are the risks involved, is it safe to use the medicine during pregnancy?  Read Full »

Dr. Deepthi

Answer: Hi, Welcome to Clofranil (Clomipramine) should not be used in pregnancy. It is a category C drug that means if potential benefits justify the risk to the fetus, then you can use. As far as of now no well-controlled studies in humans, but it will not cause anomalies but it may affect yo...  Read Full »

Please suggest alternate medication for Clomipramine.

Query: Hi doctor, I started taking Clofranil 25 mg at the sleeping time for having useless thoughts with disturbed sleep. After few years, I started hearing whistling sounds and so I started taking Seizunil 200 mg with Clofranil 25 mg and Alp 0.5 mg. Now it has been five years. I want to stop taking Clofr...  Read Full »

Dr. Vishal Anilkumar Gandhi

Answer: Hi, Welcome to If you want to stop your medication, then you need to taper off. Do not stop it abruptly. It gives you withdrawal symptoms. You should take tablet Clofranil 10 mg (Clomipramine) daily for another four weeks and then start taking it on alternate days for another four to ...  Read Full »

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