Consanguineous Transmission

Consanguineous marriage indicates union between couples who are close relatives or cousins. They are genetically related and descended from common ancestors. They cause consanguineous transmissions. The consanguineous union's offsprings have an increased risk of genetic disorders as the expression of an autosomal recessive gene is inherited from their common ancestor.

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Can I have a normal child on marrying a girl with a family history of genetic abnormalities?

Query: Hi doctor, I am planning to get married. My father got married to his elder sister's daughter, and my younger brother had cerebral palsy at birth, and my sister has a low IQ but she is manageable. In my fiance's family, her paternal grandfather is married to his sister's daughter. They have a daugh...  Read Full »

Dr. M. Pradeep Kumar

Answer: Hello, Welcome to Cerebral palsy and low intelligence quotient in your siblings need in-depth analysis. Both these problems happening in consanguineous parents cannot be taken as incidental or independent of each other. The deafness in your fiance's side needs genetic evaluation too. We...  Read Full »

My wife gave birth to a dead baby. Has it occurred as we are cousins?

Query: Hi doctor, I am married to my cousin, blood relatives. My blood group is B positive, and my wife is A positive. She gave birth to a dead baby, and it was the first pregnancy. I am deeply concerned if this because of our relationship. Please guide me.  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hi,Welcome to consanguineous marriage, the chance of spread of autosomal recessive disorder and certain congenital malformations is present.Hence, both of your CBC (complete blood count) report and HPLC (high-performance liquid chromatography) should be done to rule out hemoglobinop...  Read Full »

I got married to my relative, having the same blood group. Do I need to worry about my second baby?

Query: Hi doctor, I got married to my relative and we have the same blood group. My first baby is quite healthy and fine without any problem. Now, we are planning for the second baby. We did not check about Rh factor yet and we afraid that any problem might come in the second pregnancy. Should I worry a...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hi, Welcome to You and your husband are relatives, so in such situation prenatal or preconception counseling is beneficial to avoid the consanguineous disease transmission mainly autosomal recessive problem like thalassemia. If your blood group is Rh negative and if the fetus is Rh pos...  Read Full »

Will same blood group of couple cause any problem to the baby?

Query: Hi doctor, I am going to get married after six months. My fiance is my dad's sister's son. Our blood groups are the same B+. Will there be any problem to the baby? If yes, then what is the solution?  Read Full »

Dr. Lohit Chauhan

Answer: Hi, Welcome to The blood group will not be a problem but, there are chances of high consanguinity. Consanguineous marriages are associated with an increased risk for congenital malformations and autosomal recessive diseases, with some resultant increased postnatal mortality in the off...  Read Full »

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