Q. What is the possibility of having a normal child with a girl with a family history of genetic abnormalities?

Answered by
Dr. M. Pradeep Kumar
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Jan 12, 2022

Hi doctor,

I am planning to get married. My father got married to his elder sister's daughter, and my younger brother had cerebral palsy at birth, and my sister has a low IQ but she is manageable. In my fiance's family, her paternal grandfather is married to his sister's daughter. They have a daughter who is deaf. So please let me know if I can go ahead with this marriage proposal and have normal children without any genetic abnormalities due to the family history.



Welcome to

Cerebral palsy and low intelligence quotient in your siblings need in-depth analysis. Both these problems happening in consanguineous parents cannot be taken as incidental or independent of each other. The deafness in your fiance's side needs genetic evaluation too. We will evaluate and fix genetic etiology in persons affected on both sides of your family. Based on the genetic diagnosis made, the recurrence risk for your offspring can be predicted. If recurrence is expected, we will guide you for early diagnosis (testing fetus during pregnancy) and other possible methods of preventing a baby from being born with an abnormality.

Kindly plan accordingly.

I hope this helps.


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