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When should someone at 56 rethink depression treatment?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I am 56 years old and have been living with major depressive disorder for many years. I have mostly been using the same medications and routines for a long time, but lately it feels like I am only barely functioning rather than truly improving.

This has made me wonder whether I should speak with my doctor about changing my overall treatment approach, because I am beginning to feel that my current treatment plan may no longer be working effectively.

Would it make sense to revisit different types of therapy, medication adjustments, or newer treatment options? I am frustrated with this cycle and would appreciate your guidance.

Please help.

Hello,

Welcome to icliniq.com.

I have reviewed your query and understand your concern. Depression can affect people differently over time, and it is reasonable to reassess treatment when symptoms are no longer improving adequately.

Your history is suggestive of recurrent major depressive disorder, which is a manageable condition with the right treatment strategy.

In general, changing an antidepressant is considered when there is little or no improvement after an adequate trial at the proper dose. At the same time, augmentation strategies may be used when there is only partial improvement.

Revisiting psychotherapy approaches, behavioral modifications, and lifestyle routines can also be beneficial, as both medication and therapy play important roles in long-term management.

There are also newer treatment options available for patients whose symptoms persist despite standard treatment. These may include repetitive transcranial magnetic stimulation (rTMS), electroconvulsive therapy (ECT), or ketamine-based therapies, depending on individual circumstances and medical evaluation.

For individuals with recurrent depressive episodes, long-term maintenance treatment is often recommended to reduce the risk of relapse and improve overall functioning.

Regular follow-up with your psychiatrist can help determine whether medication adjustments, therapy changes, or newer approaches may be appropriate for you.

I hope this information helps you.

Thank you.

Medically reviewed byiCliniq medical review team

Published At May 27, 2026
Reviewed AtMay 27, 2026

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