Does high bilirubin and mild liver enlargement mean cancer?
Patient's Query
Hi doctor,
My wife is turning 40 next year. A couple of weeks ago, she went to the doctor because she had been experiencing issues with gas. About six months ago, she also noticed yellowish streaks in both of her eyes. They were not very pronounced, but if you looked closely, you could see them. I encouraged her to show this to the doctor, which she did.
The doctor ordered blood tests to check her liver and noticed that her liver was slightly enlarged. All the tests came back normal, except for the conjugated bilirubin (direct bilirubin), which was at eight. The normal range is between two and four.
I searched about this on the internet, and it shows that these are the signs of cancer. She has been feeling a bit tired for months, but it is not extreme. She has not experienced any weight loss, her appetite is normal, and nothing else seems out of the ordinary.
Please guide.
Thank you.
Hi,
Welcome to icliniq.com.
I read your query and understand your concerns.
I completely understand the fear you are feeling after reading about your wife's symptoms and discovering that they may be related to hepatocellular carcinoma, or primary liver cancer.
I want to reassure you that the symptoms you have described do not directly indicate cancer. The only symptom that might have raised your concern is jaundice, which causes the eyes to turn yellow and results in severe itching.
However, liver cancer symptoms tend to be much more severe. In the case of liver cancer, symptoms may include a swollen and distended abdomen, loss of appetite, and significant weight loss. Since none of these symptoms are present in your wife's case, she only has elevated bilirubin, so that we can consider other explanations.
Elevated bilirubin levels can result from various factors, including hepatitis, viral infections, medications she might be taking, or conditions like gallbladder stones. It is also reassuring that her liver enzymes are normal, indicating that liver function is not compromised, which further reduces the likelihood of cancer.
We can conduct a test called the alpha-fetoprotein test, which is a tumor marker that helps determine whether cancer is present. Additionally, I recommend performing an abdominal ultrasound if it is available, as it can provide valuable information.
If the ultrasound indicates a mass in the liver, we may then consider a triphasic CT scan (computed tomography). Currently, no symptoms suggest a cancer-related issue.
I hope I have answered your question.
Let me know if I can assist you further.
Thank you.
Patient's Query
Hi doctor,
Thank you so much for your reply.
If you do not mind, I would like to ask a couple of follow-up questions:
She initially visited the doctor due to problems with gas, particularly in the morning. Could this be related to an issue with her liver?
Considering that she is relatively young (39 years old), does that indicate a lower likelihood of cancer?
Are gallstones that do not present with the classic painful symptoms common?
We first noticed the yellowish streaks in her eyes about six months ago. The yellowing is not very pronounced and does not affect the entire eye. Should we expect this to have worsened if something significant had been happening during that time?
Please help.
Thank you.
Hi,
Welcome back to icliniq.com.
First, I want to reassure you that, based on your wife's symptoms and signs, there is currently nothing that closely indicates cancer. I would like to explain that gas, along with any condition affecting the liver, can cause symptoms such as gas distension, bloating, and constipation.
Additionally, liver enlargement can occur in various conditions, including fatty liver (excess fat in the liver), hepatitis (an infectious disease), hepatocellular carcinoma, and gallstones. All these conditions may lead to an increase in liver size, so when the doctor examines her, he may find that her liver size is slightly enlarged. However, this enlargement does not explicitly indicate cancer.
Regarding age, there is no specific age that is specifically associated with cancer. Hepatic carcinoma can occur at any age, so there is no particular age that would suggest she has cancer. It's also worth noting that gallstones can sometimes present without the usual symptoms or typical pain we expect.
During an examination, the doctor might find tenderness in the area, but it could also be asymptomatic. A six-month period is quite lengthy for cancer to develop undetected. If it were cancer, it would typically progress more rapidly and produce more severe symptoms.
If she noticed jaundice six months ago and has been otherwise normal since, this is not typical behavior for cancer. In particular, liver cancer usually develops more quickly, often within a couple of months, leading to significant deterioration and notable weight loss.
Therefore, if the situation has remained stable for six months, this should provide reassurance that the cancer is less likely.
I hope I have answered your question.
Let me know if I can assist you further.
Thank you.
Patient's Query
Hi doctor,
Thank you so much for your reply.
I would not bother you anymore. You have been so good, but one more thing. I will show you her test results for B-leukocyte. It has been decreasing over the years.
Could this have something to do with the liver?
Please guide.
Thank you.
Hi,
Welcome back to icliniq.com.
There is absolutely no problem at all. You can ask any question at any time. I opened the test result and tried to read it, but it was unclear. You sent a link or something that is not clear to me. Please take a screenshot of the test result and send it to me.
However, generally, the idea that the white blood cell type, specifically lymphocytes, starts to decrease over the years can occur in typical cases and has nothing to do with liver cancer. But if there is a severe decrease and the result is affecting her general condition, then this could be related to cases of liver cirrhosis, where the liver stops working completely. This leads to portal hypertension, which causes the spleen to be affected and start breaking down white blood cells.
I do not think she has reached that stage, because at that stage, there would be many other symptoms, much more than jaundice. Therefore, I do not believe the breakdown of white blood cells is occurring due to a liver problem; the liver takes a very long time to reach that point.
I hope you can send the test more clearly, and I hope my answer has clarified the situation for you. The breakdown of white blood cells due to a liver problem is doubtful.
I hope I have answered your question.
Let me know if I can assist you further.
Thank you.
Patient's Query
Hi doctor,
Thank you for your reply.
I have tried to send it again.
Please guide.
Thank you.
Hi,
Welcome back to icliniq.com.
I reviewed the image you sent me (attachment removed to protect the patient's identity). I believe there is a decrease in white blood cells. This can have many causes, including age. As one gets older, it naturally decreases. There may be a chronic inflammation somewhere that we are unaware of. It could be chronic inflammation in the joints, liver, colon, bone itself, or bone marrow. There could be chronic inflammation in the lymph nodes, in cancer, in the hepatocytes, or in carcinoma. There are many possibilities.
However, the point is that there are no other accompanying issues. It could be related to immunity, to the immune system. It could also be related to hormonal issues. But it is not something related to cancer. Cancer does not act chronically over years.
Cancer typically shows its signs within days or in other ways, rather than over years. This is what I wanted to convey to you. So I also see that all of these issues are far from cancer, specifically far from hepatocellular carcinoma.
I hope I have answered your question.
Let me know if I can assist you further.
Thank you.
Patient's Query
Hi doctor,
Thank you for your reply.
I forgot to add another test that was lower than before for her. I will attach it and see if you understand it, and if it is concerning regarding the other symptoms and tests.
Please help.
Thank you.
Hi,
Welcome back to icliniq.com.
I hope you and your wife are well, and I hope she is feeling better today.
I am here for you at any time. If you would like to send any test, I am at your service, but I did not receive the test list from you. I opened it to check the file, but I did not find any attached file at all. Please, if you could take a picture of it and send it to me. I am at your service anytime.
I hope I have answered your question.
Let me know if I can assist you further.
Thank you.
Patient's Query
Hi doctor,
Thank you for your reply.
Yes, I tried uploading it before, but it would not let me until I paid for another question, unfortunately. Here it comes again.My wife is still feeling perfectly fine otherwise.
Please help.
Thank you.
Hi,
Welcome back to icliniq.com.
I am very sorry that you had to pay twice, but in the first message, the test really did not arrive. I have now seen it and checked it. Usually, it measures the hemoglobin level within the blood, specifically inside the red blood cells. And since it is low, this indicates a type of anemia. But its decrease is not severe to the point that we would say there is cancer or something that caused this anemia.
No, the decrease is logical, and it could be due to a low iron level, a deficiency in the vitamin B complex, or that she simply needs to eat a bit more. In other words, we need to focus more on red meat, she should take iron supplements, and she needs to treat her anemia. But there is nothing dangerous that suggests it is related to cancer.
I hope I have answered your question.
Let me know if I can assist you further.
Thank you.
Patient's Query
Hi doctor,
Thank you for your reply.
The doctor got back to her with good news, although it is still a bit confusing to me. Maybe I worry too much.
The doctor said my wife's total bilirubin was 26 and her conjugated bilirubin was eight. The value of eight is a slight increase, but the rest of her liver tests were regular, so there is nothing to worry about. One of the other liver tests was within the reference range, but it was just at the lower end of the range.
She also said the yellowish streaks in her eyes are not related to bilirubin levels and referred her to an eye specialist.
Do you agree?
Please help.
Thank you.
Hi,
Welcome back to icliniq.com.
I hope you are well, and I am sorry for the late reply. First of all, I am very happy and pleased that your wife's tests and examination results came out normal. This is very good, and I hope the fear and anxiety you had are now gone.
Regarding the bilirubin values you sent, of course, these depend on the reference ranges of each lab. Every lab in every country has its own different reference values. As long as the numbers are within the normal range of that reference, then we are reassured. Even if they are at the upper limit, that just means that if she drinks alcohol, she should reduce it, and if she is overweight, she should try to lose some weight. All these factors affect liver efficiency. But as long as we are within the normal range, everything is fine.
Regarding the eye jaundice, we can check with an ophthalmology specialist to tell us what it is. Some people really do have yellowish lines in the sclera, and this can be related to fat deposition in the system itself. It does not mean that there is a problem with the liver or another system; it is specifically related to the eye. The ophthalmologist will give us their opinion, and that will make a big difference.
I hope I have answered your question.
Let me know if I can assist you further.
Thank you.
Same symptoms don't mean you have the same problem. Consult a doctor now!
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