HomeAnswersInternal Medicineerythema nodosumWhy do I have nodules under the skin which cause pain while touching?

I have some nodules under the skin with pain while touching. What is the problem?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

Dr. K. Shobana

Published At November 27, 2020
Reviewed AtOctober 19, 2022

Patient's Query

Hi doctor,

I am a 37-year-old female with a weight of 65 kilograms and a height of five feet five inches. I saw some nodules under my skin with pain while touching. I have a hard mass under my skin and it spreads to different parts of the body. I started to have this issue four years back. My blood test shows WBC of 3300 WBC per microliter, RBC of 2.8 million cells/mcL, and ESR of 100 mm/hr. All my other parameters are normal. I have a fever every afternoon along with joint pain. I am physically weak and I have a weight loss of 8 kilograms. I also have varicose vein pain. My stomach remains full even when I take little food. When I eat more, I have vomiting. I have done two bone marrow biopsies, two skin biopsies, lymph node biopsy, lip biopsy, ultrasound scan, many TB tests, nerve tests, and SPECT CT scan. There is no malignancy. All my results are negative. My doctor gave me medicines for TB for two weeks. But it did not help me. I am not taking any other medications. I could not find the cause. Some doctor say me that this is panniculitis. Kindly suggest.

Answered by Dr. Sadaf Mustafa

Hi,

Welcome to icliniq.com.

Thank you for sharing your reports and providing a detailed history. I have not seen your lesions visually. But your condition strongly favors erythema nodosum. Your fatigue occurs due to vitamin D and B12 deficiency. You can start taking vitamin B12 1000 mcg daily. You can also take vitamin D 50,000 IU once a week. I do not know whether you have any issues in your abdomen. But erythema nodosum has an association with Crohn's disease.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Sadaf Mustafa
Dr. Sadaf Mustafa

Internal Medicine

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