Q. I have some nodules under the skin with pain while touching. What is the problem?

Answered by
Dr. Sadaf Mustafa
and medically reviewed by Dr. K Shobana
This is a premium question & answer published on Nov 27, 2020 and last reviewed on: Jun 24, 2021

Hi doctor,

I am a 37-year-old female with a weight of 65 kilograms and a height of five feet five inches. I saw some nodules under my skin with pain while touching. I have a hard mass under my skin and it spreads to different parts of the body. I started to have this issue four years back. My blood test shows WBC of 3300 WBC per microliter, RBC of 2.8 million cells/mcL, and ESR of 100 mm/hr. All my other parameters are normal. I have a fever every afternoon along with joint pain. I am physically weak and I have a weight loss of 8 kilograms. I also have varicose vein pain. My stomach remains full even when I take little food. When I eat more, I have vomiting. I have done two bone marrow biopsies, two skin biopsies, lymph node biopsy, lip biopsy, ultrasound scan, many TB tests, nerve tests, and SPECT CT scan. There is no malignancy. All my results are negative. My doctor gave me medicines for TB for two weeks. But it did not help me. I am not taking any other medications. I could not find the cause. Some doctor say me that this is panniculitis. Kindly suggest.



Welcome to

Thank you for sharing your reports and providing a detailed history. I have not seen your lesions visually. But your condition strongly favors erythema nodosum. Your fatigue occurs due to vitamin D and B12 deficiency. You can start taking vitamin B12 1000 mcg daily. You can also take vitamin D 50,000 IU once a week. I do not know whether you have any issues in your abdomen. But erythema nodosum has an association with Crohn's disease.

Was this answer helpful?


Same symptoms doesn’t mean you have the same problem. Consult a doctor now!

Related Questions:
Crohn's Disease

Biopsy - The doctor might take a tissue sample during endoscopy or colonoscopy ...   Read full

Nutritional Management of Children with Crohn’s Disease and Ulcerative Colitis

Avoid Food Sensitivities Many times, it is observed that the children suffering from inflammatory bowel diseases develop intolerances towards certain foods ...   Read full

What is the treatment for Crohn's disease?

As per your complaints and previous diagnosis of IBD (irritable bowel disease), it falls under Grahani disease ...   Read full


Also Read Answers From:

ideaComprehensive Medical Second Opinion.Submit your Case

Also Read

Nipah Virus: Stay Safe from This Deadly Disease
The recent speculation about the spread of the Nipah virus in a Southern State in India has surely brought jittery feeli...  Read more»
What to Do When Someone Turns COVID-Positive At Home?
COVID-19 pandemic has affected so many people, and many of them are advised for home care. This article explains the pre...  Read more»
Guidelines for Management of COVID-19 In Children
Amidst the concerns that children will be the target in the third wave of COVID-19, they have come up with certain guide...  Read more»

Ask your health query to a doctor online?

Ask an Internal Medicine Physician Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website.