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Can Fluoxetine cause disturbed sleep?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hi doctor,

I am very sad, and I am surrounded by negative thoughts and anxiety. I have taken Fluoxetine (Fludac 20) for 6 weeks. Now I am fine, but I wake up early in the morning around 3.30 AM. Hence having disturbed sleep in the morning. My doctor changed medicine to Flunil 40. I think this dose is not required. Kindly advice me to avoid sexual side effects from this medicine. Thank you.

Answered by Dr. Saraswat Kumarshri Shriniwas

Education:

MBBS

Professional Bio:

Dr. Saraswat Kumarshri Shriniwas is a Psychiatrist with 19 years' expertise in Psychotherapy, Sexology, Counselling, and Sleep Medicine. He holds an MBBS from Maharashtra University of Health Sciences (2004) and his D.P.M from the College of Physicians & Surgeons of Mumbai (2008). Dr. Shriniwas specializes in diagnosing, preventing, and treating mental disorders, assessing patients for comprehensive care at Mind Care Peace Centre, Jalna, Maharashtra.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome to icliniq.com.

Fluoxetine is known to cause significant insomnia in many patients as it is an activating drug. Being an selective serotonin reuptake inhibitor (SSRI) Fluoxetine causes sexual dysfunction. Both these side effects can be treated by taking tablet Trazodone (brand name Trazaril) 25 mg at night time. It antagonizes the side effects of Fluoxetine. After two weeks, if needed, the dose can be increased to 50 mg.

The Probable causes

The probable cause is Fluoxetine-induced sexual dysfunction or insomnia.

Probable diagnosis

The probable diagnosis is SSRI-induced sexual dysfunction.

Treatment plan

The treatment plan is Tablet Trazodone 25 mg at night time.

Patient's Query

Thank u doctor,

My question is, do I require Fluoxetine 40 mg? Or is 20 mg fine? Kindly suggest. Thank you.

Answered by Dr. Saraswat Kumarshri Shriniwas

Education:

MBBS

Professional Bio:

Dr. Saraswat Kumarshri Shriniwas is a Psychiatrist with 19 years' expertise in Psychotherapy, Sexology, Counselling, and Sleep Medicine. He holds an MBBS from Maharashtra University of Health Sciences (2004) and his D.P.M from the College of Physicians & Surgeons of Mumbai (2008). Dr. Shriniwas specializes in diagnosing, preventing, and treating mental disorders, assessing patients for comprehensive care at Mind Care Peace Centre, Jalna, Maharashtra.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome back to icliniq.com.

You have not mentioned, for what condition you are taking Fluoxetine, and how are the symptoms currently. If your problems are sleep disturbance and sexual dysfunction, then you can continue with Fluoxetine 20 mg. However, if you still have some symptoms of the previous disorder for which you were taking Fluoxetine (depression, panic, obsessive-compulsive disorder (OCD), etc.,) and they are there even after taking 20 mg, then you might need 40 mg. In both cases, I would advise you to take Trazodone along with Fluoxetine.

Medically reviewed by Dr. Sneha Kannan
Published At February 26, 2016
Reviewed At April 1, 2025

Education:

MBBS

Professional Bio:

Dr. Saraswat Kumarshri Shriniwas is a Psychiatrist with 19 years' expertise in Psychotherapy, Sexology, Counselling, and Sleep Medicine. He holds an MBBS from Maharashtra University of Health Sciences (2004) and his D.P.M from the College of Physicians & Surgeons of Mumbai (2008). Dr. Shriniwas specializes in diagnosing, preventing, and treating mental disorders, assessing patients for comprehensive care at Mind Care Peace Centre, Jalna, Maharashtra.

This doctor is not available for online consultations on the platform anymore.

Education:

BDS

Professional Bio:

Dr. Sneha Kannan is a skilled Dental Surgeon with expertise in providing general dental care, including scaling, fillings, and preventive treatments. She does oral surgery procedures such as extractions and minor surgical interventions. She does procedures in restorative dentistry, including crowns, bridges, and dentures. She is an expert in doing endodontic treatments such as root canal therapy. She is well-versed in doing procedures in cosmetic dentistry, including teeth whitening and smile correction. She can provide pediatric dental care for children’s oral health and preventive treatments. She promotes oral hygiene awareness and preventive dental practices.  

This doctor is not available for online consultations on the platform anymore.

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Education:

MBBS

Professional Bio:

Dr. Saraswat Kumarshri Shriniwas is a Psychiatrist with 19 years' expertise in Psychotherapy, Sexology, Counselling, and Sleep Medicine. He holds an MBBS from Maharashtra University of Health Sciences (2004) and his D.P.M from the College of Physicians & Surgeons of Mumbai (2008). Dr. Shriniwas specializes in diagnosing, preventing, and treating mental disorders, assessing patients for comprehensive care at Mind Care Peace Centre, Jalna, Maharashtra.

This doctor is not available for online consultations on the platform anymore.

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