My father's blood reports show increased hemoglobin levels and the presence of anisocytosis in RBC. Kindly help.

Q. What do high hemoglobin levels and anisocytosis in RBC indicate in a 48-year-old male?

Answered by
Dr. Mahmoud Ahmed Abdelrahman Abouibrahim
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Dec 03, 2022 and last reviewed on: Dec 06, 2022

Hello doctor,

My father is 48 years old. One month back, his CBC reports revealed a high Hb, HCT, and RBC. After one week, CBC was done again, and all three values came down, and now they all are normal. His Hb is 17 g/dL, RBC is 5.5 mc/L, and HCT is 50 %. But his recent blood reports revealed the presence of anisocytosis in RBC. We are very confused and tense about his health because he sometimes feels weak and tired slightly. Also, his blood pressure shows fluctuations. Sometimes it gets high and sometimes low, but most of the time, it remains normal. Three months ago, he was on ayurvedic medication for an anal fistula which was operated on.

Thank you.



Welcome to

I read your query and understand your concern.

I have checked the attached reports (attachment removed to protect the patient's identity). Your father's high hemoglobin level is most likely due to primary erythrocytosis (polycythemia vera ), which is due to hyperfunction of the bone marrow. High hemoglobin may cause hyperviscosity, and antiplatelet medications are required to prevent thrombosis. In addition, Phlebotomy weekly is required to keep HCT (hematocrit) around 45 %.

Thank you.

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