HomeAnswersHematologywhite blood cellsWhat does high WBC and neutrophil with immature granulocytes and low lymphocytes indicate?

What could be the reason for high WBC and neutrophils with immature granulocytes?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

Dr. Vinodhini J.

Published At June 6, 2020
Reviewed AtDecember 21, 2023

Patient's Query

Hi doctor,

I just received my blood test WBC is 22000, neutrophils are 8700, high absolute immature granulocytes and low lymphocytes. I have noticed that for three years my blood tests have been on the high levels for WBC. Should I be concerned? I have been in and out and they never call me for a follow up. Maybe I should change the doctor? Also, can Phentermine be the cause of this? I only took it for two days before the blood test. I am a 39-year-old female. I have bone pain, neck pain, dizziness, and hair loss.

Hello,

Welcome to icliniq.com.

Following is my opinion for your asked question.

Your total WBC count and neutrophils are high. Mild increase of immature granulocytes and high count with neutrophilia could be due to infection or inflammation in the body. Your detailed physical examination and investigation should be done to find the underlying cause.

For your complaint you can investigate further with ANA (antinuclear antibody) estimation, USG (ultrasound) abdomen, Vitamin D estimation, serum calcium estimation, blood pressure measurement, and blood sugar estimation. Your ear examination also should be done.

Antibiotic courses can be prescribed as per the provided report. However, before that physical examination and above investigation can be done. You need to follow up your CBC (complete blood count) with peripheral smear examination report after a few days to check values once again. You can consult a good internal medicine specialist for your examination and investigation accordingly.

Patient's Query

Thank you doctor,

My ANA test came back with high RNP. Can this mean MCTD?

Hello,

Welcome back to icliniq.com.

Following is my answer to your asked question.

It is good that you have investigated further with the ANA test. I could not see your ANA report but presuming that mostly it will also be positive because your RNP (ribonuclear protein) antibody test is positive. The anti RNP antibody positivity was seen in mix connective tissue disease, SLE (systemic lupus erythematosus), or scleroderma like autoimmune diseases.

Hence your diagnosis is autoimmune disease mostly mixed connective tissue disease. It is the cause of your elevated neutrophils as per my opinion. You should consult a rheumatologist or good physician nearby for detailed physical examination and treatment accordingly.

I hope this helps.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Goswami Parth Rajendragiri
Dr. Goswami Parth Rajendragiri

Pathology

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