HomeAnswersDermatologyhyperpigmentationAfter applying Hydroquinone cream, my skin turned dark. Kindly help.

How do I treat the hyper pigmentation caused by Hydroquinone application in my neck?


The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

Dr. K. Shobana

Published At October 5, 2022
Reviewed AtSeptember 21, 2023

Patient's Query

Hello doctor,

I applied Hydroquinone cream, and now I am facing a hyperpigmentation problem. My skin turned dark. I have been under medication, applying sunscreen and skin rejuvenation cream as suggested by my dermatologist. Still, I feel only a little improvement and do not get my neck color back. Please tell me what I should do. Will it go or not? I am going through depression. Please help and suggest me some cream. I have heard about Meladerm and wanted to know how it is.

Answered by Dr. Sushil Kakkar


Welcome to icliniq.com.

I would keep a possibility of pseudoacanthosis nigricans. Pseudoacanthosis nigricans is a skin disorder with darker, thick, velvety skin in body folds and creases. The skin becomes dark, velvety, and thick in the back and sides of the neck, armpits, thighs, elbows, and knees. Acanthosis nigricans usually appear slowly and do not cause symptoms other than skin changes. It typically occurs in individuals younger than 40, may be genetically inherited, and is associated with obesity or endocrinopathies, such as hypothyroidism, acromegaly, polycystic ovary disease, insulin-resistant diabetes, or Cushing's disease. The majority of cases of acanthosis nigricans are associated with obesity or idiopathy. This is likely because of insulin resistance and is more likely to occur in darker-skinned persons. This is also known as Pseudo-Acanthosis Nigricans. Acanthosis nigricans is likely to improve when a known cause is removed. For example, obesity-related acanthosis nigricans will improve with weight loss. People with acanthosis nigricans, in general, should be screened for diabetes. Weight loss and controlling blood glucose levels through exercise and diet often improve symptoms. I would suggest Topical Tretinoin 0.05 % cream once daily at night helps to lighten pigmentation; and weight loss, exercise, and diet management should be followed. Alpha-Lipoic acid has been shown to increase insulin sensitivity and thereby reverse the pseudo-acanthosis nigricans resulting from insulin resistance, as in the case of obesity and diabetes. It is commercially available for prescription in acanthosis nigricans. You can also try tablet Nexna (N-Acetyl Cysteine, Inositol, Alpha Lipoic Acid, Chromium Picolinate, Zinc Gluconate) - twice daily for 1 to 2 months. However, you may consult a specialist doctor and have the medications as instructed.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Sushil Kakkar
Dr. Sushil Kakkar


Community Banner Mobile
By subscribing, I agree to iCliniq's Terms & Privacy Policy.

Ask your health query to a doctor online


*guaranteed answer within 4 hours

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.

This website uses cookies to ensure you get the best experience on our website. iCliniq privacy policy