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My pregnant wife received a positive ICT result. Please assist.
Query: Hi, My 33-year-old wife is 30 weeks pregnant. This is her second pregnancy. Her blood group is B negative, and my blood group is O positive. However, her ICT test got positive (value 1:8). She has been taking medicine for ulcerative colitis for four years (Mesalazine 2400 mg daily). She is also taki... Read Full »
Answer: Hello, Welcome to icliniq.com. I read your query and understand your concern. When an Rh-negative woman reveals an indirect Coombs test (ICT) positive (more than 1:32 titer), then amniocentesis is performed, and the optical density of the amniotic fluid is determined by spectrophotometry (a sampl... Read Full »
Should I take anti-D injection before conceiving for the second time with negative blood group?
Query: Hello doctor, I am 35 years old, and I have a 5-year-old child delivered through normal delivery. My first child and I share the same blood group, which is B negative. I had a six-week abortion with pills five years ago, due to some miscommunication I missed taking anti-D. Now I am planning for a se... Read Full »
Answer: Hello, Welcome to icliniq.com. Yes, you need to get an ICT (Indirect Coombs test). Since the previous baby is also negative, and the abortion you had was with a pill, so most likely, the test will be negative, but do get it done. You can plan pregnancy, but the most important thing you have to ke... Read Full »
Is second pregnancy safe in Rh negative mother after anti-D injection?
Query: Hello doctor, My blood group is O +ve and my wife's is O -ve. Our child was born four years back and he is O +ve. After his birth, my wife was given an injection to avoid future complications arising due to opposite blood groups of my wife and son. Two years later, she had an abortion. The pregnancy... Read Full »
Answer: Hi, Welcome to icliniq.com. As she has received injection after first delivery, there is nothing to worry about. So relax and do not worry. However, if you have a doubt then get an indirect Coombs test to make sure that there is no risk. The miscarriage could be because of some other cause and not... Read Full »
How does Coombs test diagnose cold-agglutinin-disease?
Query: Hello doctor, I am trying to understand how a Coombs test would be used to diagnose me for cold-agglutinin-disease. Can you please help explain in understandable terms what that would do? I am confused between direct and indirect tests. Read Full »
Dr. Goswami Parth Rajendragiri
Answer: Hello, Welcome to icliniq.com. I am trying to explain to you about the Coombs test. Basically, this test detects antibody-coated red blood cells. The direct Coombs test detects antibody coated on red blood cells. In cold agglutinin disease, the IgM antibody coat the red blood cells. So direct Coo... Read Full »