What precautions can be taken during pregnancy if mother is Rh-negative and ICT reports are positive?

Hello,

Welcome to icliniq.com.

I read your query and understand your concern.

When an Rh-negative woman reveals an indirect Coombs test (ICT) positive (more than 1:32 titer), then amniocentesis is performed, and the optical density of the amniotic fluid is determined by spectrophotometry (a sample of the amniotic fluid is collected from the mother with the help of a needle). If the bilirubin level is found to be in the danger zone, as seen by plotting in Queenan and Liley curve, then cordocentesis and fetal exchange transfusion are performed to manage these women and improve neonatal outcomes.

This is not required for your wife as the values are mildly high. But to avoid any complications, I suggest you take the following measures-

1. Prophylactic anti-D injections around 28 weeks of pregnancy.

2. Doppler study - a simple non-invasive technique of monitoring fetal anemia in Rh isoimmunized pregnancy.

3. Intravenous immune globulin (IVIG) helps to prevent hemolysis (if anything turns south, we have this medicine as a safety measure).

Thank you.