My dad is 78 years old and was diagosed with stage 4 transitional cell carcinoma of left kidney for which he underwent a neprourectomy. It is six months now and he took immunotherapy for the same. He had three doses of Ketruda but with third dose he developed pneumonitis and changes in lung. He had blood culture but no infection was present so they treated with steroids for 10 days, after stopping steroids he developed some tiredness and fever for which he was put on antibiotic Bactrim. But after he took that for a few days, he was better but just two days back he developed extreme drowsiness, slurring of speech and confusion. He was advised to rush to a nephrologist because his creatinine was 3.7 and his HB was 7. His potassium levels were high too and ESR was 120, lymphocytes were low.
So, they took out all the drugs he is presently on to stabilise his creatinine and potassium levels and transfused blood. My question is he was on maintainance drugs for 40 years of which Sartel 40 for hypertension, Glyciphage for diabetes, Liofen and Gabantin for trigeminal neuralgia and Ativan for anxiety have been withheld. Do these drugs cause any interference with his kidneys? Please let me know because I want a second opinion and be double sure that this is the right thing to do.
Welcome to icliniq.com.
I have gone through the details about your history. Cause of deranged renal function is multifactorial. First of all, Ketruda that is Pembrulizumab can cause interstitial nephritis, that can cause damage to kidney and rise of creatinine.
Sartel is for blood pressurebut it can cause rise in creatinine in acute setting such as after surgical stress, so stopping is a good decision. When there is a damage to kidney, drug such as Gabapentin get accumulated in body and can cause neurological symptoms as you told. It will subside gradually as kidney function improves.
So, from current medicines, you stop Parozep until his kidney recover, for blood pressure take Amlodipine 5 mg (as the blood pressure is normal now) (attachment removed to protect patient identity). Get urine routine done and urine protein creatinine ratio and if creatinine continue to rise, a kidney biopsy may be needed. Otherwise, control of potassium and urine output as per regular protocol of treating nephrologist.
Take care and would like to know further detail and progress, wishing him a speedy recovery.
Thank you very much for your reply. I have further queries. They had done an ultrasound which showed grade 2 renal parenchymal changes and mild ascites. Bilateral basal consolidations in lung and minimal pleural effusions. They have restarted Activin and Gabantin, the creatinine level was 3.49, and all other parameters were improving. Overall my father is feeling much better. His urine output is good, and general parameters are all stable. Can you please advice? His urine and blood culture reports are negative. He has no other problem. They have also given erythropoietin injection.
Sorry, I do not have any reports. But, I know his kidney was normal until a few weeks back, normal in size and normal echotexture. This change in appearance is very acute, and now kidney is enlarged with increased cortical echotexture and accentuated corticomedullary differentiation. They have reported as grade 2 renal parenchymal disease. His blood pressure and diabetes are in control. They have reduced dosage of Gabapentin and Activin because my dad has been on them for 40 years and he cannot handle withdrawal, so they have cut the dosage to half. This condition of the kidney is a very acute and sudden onset after taking Bactrim, and he experienced all the symptoms that we found out that he had raised creatinine. They have been testing urine and blood and even performing a regular ultrasound for the three doses of Ketruda. All these happened before he went for the 4th dose. I do not have films because I am not with him.
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Basically, USG findings depend on sonologist who is performing the scan. Considering it as acute, 70% chances it will recover, considering it happened after the third dose, it needs kidney biopsy to rule out interstitial nephritis. Also, other cause could be fluctuations in BP; hence dehydration needs to be ruled out.
I want to update you with the present situation. My dad's creatinine was 3.4 yesterday and today 3.49. The Nephrologist has said that they will not do a biopsy and they are treating with Nodosis DS, Bistla, Alfaren, and Silodal D. Otherwise, his blood pressure and diabetes are in control. His urine showed gram-negative rods and few pus cells but the culture was sterile. Overall he is feeling good. There are no other complaints. Any of your suggestions would be useful. Thank you.
Welcome back to icliniq.com.
I am happy to hear. It is good that the condition is stabilized. Please, wait and watch. Let us hope for the best.
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