Is treatment necessary for Lyme disease?

Q. I feel fatigue and numb with peripheral neuropathy. Does this indicate positive Lyme disease?

Answered by
Dr. Srivastava Durgesh
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Dec 20, 2019 and last reviewed on: Jul 14, 2023

Hi doctor,

One laboratory report says that I am positive for Lyme disease and another lab report says it is negative. Both used serum and western blot. I was in tick-borne Lyme areas overseas but do not recall a bite specifically. I have a positive ANA test (speckled pattern 1:80), anti-ds-DNA 8 iU/ml. I am negative on all the autoimmune disease antibody tests (Sjorgens, lupus, etc). I have low vitamin D, low B12, low calcium, and low albumin. I have mild neutropenia. CRP is a bit high at 6.7. Alpha 2 globulin is mildly elevated. I am wondering if the ANA tear has any significance? I am quite unwell with extreme fatigue, numbness and a heavy leg on one side, peripheral neuropathy (numbness, tingling, spasms), and ankle edema and I have put on 10 kg. I am usually quite thin (59 kg and 178 cm), but now I am 71 kg and it is all in my stomach (fluid?). I have had skin nodules and my scalp feels swollen and I have some hair loss/thinning. Fingernails have vertical ridges and no moons. I have tried antibiotics, anti-fungal oral, and topical. I was a frequent traveler for work and thought maybe got something there. I am so confused as to if I should commence treatment for Lyme disease as I do not know if I have it or not. I am currently taking Vitamin B12, vitamin D supplements, and Nystatin. The illness has been chronic for the last three years. Symptoms already discussed except I forgot to say periods suddenly stopped about 18 months ago. It might be pre-menopause but the strange thing is they did not slow down or become irregular, just bang stopped.



Welcome to

Your ANA (antinuclear antibody) report is not much significant. Lyme disease test IgG positivity reflects its chronic presence. Many of your neurological symptoms could be attributed to it. However, few symptoms need further evaluation by a rheumatologist, because a physical examination is necessary. Your nail ridges and a few skin changes could be due to Psoriasis or Reiter's disease which may also cause fatigue and joint pains. I would suggest you take treatment for Lyme disease because it is not much longer. Also, you should get yourself evaluated by a rheumatologist, for the presence of inflammatory arthritis.

I hope this helps.

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