One laboratory report says that I am positive for Lyme disease and another lab report says it is negative. Both used serum and western blot. I was in tick-borne Lyme areas overseas but do not recall a bite specifically. I have a positive ANA test (speckled pattern 1:80), anti-ds-DNA 8 iU/ml. I am negative on all the autoimmune disease antibody tests (Sjorgens, lupus, etc). I have low vitamin D, low B12, low calcium, and low albumin. I have mild neutropenia. CRP is a bit high at 6.7. Alpha 2 globulin is mildly elevated. I am wondering if the ANA tear has any significance? I am quite unwell with extreme fatigue, numbness and a heavy leg on one side, peripheral neuropathy (numbness, tingling, spasms), and ankle edema and I have put on 10 kg. I am usually quite thin (59 kg and 178 cm), but now I am 71 kg and it is all in my stomach (fluid?). I have had skin nodules and my scalp feels swollen and I have some hair loss/thinning. Fingernails have vertical ridges and no moons. I have tried antibiotics, anti-fungal oral, and topical. I was a frequent traveler for work and thought maybe got something there. I am so confused as to if I should commence treatment for Lyme disease as I do not know if I have it or not. I am currently taking Vitamin B12, vitamin D supplements, and Nystatin. The illness has been chronic for the last three years. Symptoms already discussed except I forgot to say periods suddenly stopped about 18 months ago. It might be pre-menopause but the strange thing is they did not slow down or become irregular, just bang stopped.