What can cause very sore joints and muscles?

Q. I have been sick with very sore joints and muscles. What could it be?

Answered by
Dr. Prakash. H. M.
and medically reviewed by Dr. Sneha Kannan
This is a premium question & answer published on Feb 17, 2016 and last reviewed on: May 29, 2023

Hi doctor,

I have been sick for the last two years with the following symptoms. Fatigue, ringing in ears, very sore joints, sore muscles, follicular carcinoma, passing out, and extreme headaches. I am taking Synthroid currently. I just had a flow cytometry and numerous bouts of blood work. I have attached that for your reference.

Please help.



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Based on test results, my opinion is, it could be chronic Lyme disease. Low CD57 with additional symptoms provided except follicular carcinoma, could be due to chronic Lyme disease.

Chronic Lyme disease is associated with a decrease in the CD57 lymphocyte subset that may persist over 10 years. The decrease in CD57 cells appears to reflect a selective immunologic abnormality in patients with chronic Borrelia infection. Longer therapy, maybe up to 11 months with Tetracycline may be necessary. It could be helpful. Your doctor can guide you with further management.

Treatment plan:

1. Prolonged antibiotic therapy could be helpful.

2. Any co-infections present should be treated first.

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