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HomeAnswersHematologylymphocytosisI have been diagnosed with monoclonal B cell lymphocytosis. Kindly advice.

Kindly advice on monoclonal B cell lymphocytosis.


The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

Dr. Nithila. A

Published At July 18, 2019
Reviewed AtJune 5, 2023

Patient's Query

Hello doctor,

I am 46 years old. I have been diagnosed with monoclonal B cell lymphocytosis. B-cell markers CD19 is 36 %, CD 20 is 33 %, and CD 22 is 3%. Dual expression Cd19/Cd5 is 31 %, Cd19/Cd23 is 31%, Cd19/Cd10 1 %. Blood was lymphoid gated. B-cell population co-expresses CD 45, 5, 19, 23, 20 dim and without surface light chain expression, and these comprise 31 % of lymphocytes 1.9 times.

Kindly advice.

Answered by Dr. Prakash. H. M.


Welcome to icliniq.com.

Based on your query, my opinion is as follows,

1. Going through the markers and the count, a diagnosis of MBL (monoclonal B-cell lymphocytosis) can be thought of.

2. Absolute counts are only mildly increased. Need to watch for rising counts and any lymph nodes in the future.

3. Usually, the population, if checked as a whole, more than 7 % show MBL. However, progression to CLL is low. Only follow-up with blood counts and clinical examination for lymph nodes is necessary. No further tests are necessary for now. I hope it helps. Any further queries, here to help again.

Investigations to be done

Repeat counts after six months.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Prakash. H. M.
Dr. Prakash. H. M.


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