Lymphocytosis occurs when there is increased production of lymphocytes in the body than the normal range. Lymphocytosis occurs in cases of acute viral infections, such as infectious mononucleosis, hepatitis, cytomegalovirus infection, toxoplasmosis, tuberculosis, and brucellosis. The symptoms are fever, loss of appetite, weight loss, shortness of breath, fatigue, and fullness of the stomach. To reduce its count, it is necessary to take vitamin C, antioxidants, and omega-3 fatty acids in the diet. It is good to avoid taking foods rich in sugar, fat, and salt.

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I am having weakness, high fever and body pain. What is the reason?

Query: Hello doctor, I am 57-year-old male. I am facing weakness and high fever and body pain symptoms for a while now. Upon doing some routine tests with a local clinic, the test values are as below: RBC count- 5.48. Hemoglobin- 8.16. Hematocrit- 28.9. MCV- 52.71. MCH- 14.88. MCHC- 28.24. RC distribution...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to Fever, weakness, and lymphocytosis in CBC are suggestive of viral infection. Symptomatic management is done with nonsteroid anti-inflammatory drugs. Your physical examination should be done first which includes lymph nodes, spleen, liver palpation, auscultation, etc....  Read Full »

Percentage of B cells is high. Is it leukemia?

Query: Hello doctor,Here are my immunohistochemical results of peripheral blood: Absolute lymphocyte count 5812/uL reference (1000 to 3300) with CD19 (B cells) 62% reference (3 to 20%), CD45 positive, CD10 positive, and CD5 negative. How do we know if it is leukemia or not? Doctors in our town cannot inter...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to At the age of 55 years, if persistent lymphocytosis is seen, then CLL (chronic lymphocytic leukemia) should be ruled out. For that, monoclonality should be confirmed by flow cytometry investigation and need bone marrow study apart from a peripheral smear examinatio...  Read Full »

Do my blood test results indicate that I have cancer?

Query: Hello doctor, Blood tests show high leukocytes of 12000 per mL with lymphocytosis and an elevated alkaline phosphatase at 162 u/L. Kindly suggest further tests to rule out cancers and lymphoma.  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to You need to repeat your CBC (complete blood count) after three to five days. If lymphocytes count is normal then the chances of cancer are very less. If lymphocytes count remains persistently high then further workup as follow. Peripheral smear examination report...  Read Full »

2 years and 6 months old with abnormal CBC test results. Please advice.

Query: Hello doctor, 2 years and 6 months old with abnormal CBC test results (two tests seven weeks apart). First tested because of enlarged lymph node (only one side) in neck. Node has reduced in size to what appears normal. Low MCHC (just barely outside range of 32.0 to 36.0) 31.3. Low NE % of 26.1 Auto ...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to Your CBC report is suggestive of lymphocytosis (attachment removed to protect patient identity). The common cause for lymphocytosis is viral infection. The enlarged lymph node could be due to that. Now, your enlarged node return to normal size as per history, so sugg...  Read Full »

I have been diagnosed with monoclonal B cell lymphocytosis. Kindly advice.

Query: Hello doctor, I am 46 years old. I have been diagnosed with monoclonal B cell lymphocytosis. B-cell markers CD19 is 36 %, CD 20 is 33 %, and CD 22 is 3%. Dual expression Cd19/Cd5 is 31 %, Cd19/Cd23 is 31%, Cd19/Cd10 1 %. Blood was lymphoid gated. B-cell population co-expresses CD 45, 5, 19, 23, 20 d...  Read Full »

Dr. Prakash H. M

Answer: Hello, Welcome to Based on your query, my opinion is as follows, 1. Going through the markers and the count, a diagnosis of MBL (monoclonal B-cell lymphocytosis) can be thought of. 2. Absolute counts are only mildly increased. Need to watch for rising counts and any lymph nodes in t...  Read Full »

Ferritin level has decreased in spite of taking iron supplements. Should I worry?

Query: Hello doctor, I am a 21 year old female. Yesterday, doctors have checked my blood. I am visiting a hospital frequently as I have iron deficiency anemia. The thing I am scared about is, my doctor asked me why my ferritin has not increased (just the opposite, it has decreased from 5.79 to 5.77) after...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to In viral infection, lymphocytosis means increased lymphocytes and neutrophil is relatively low because of increased lymphocytes. Platelet can be high in iron deficiency anemia. It is not a matter of worry just now. You can provide your reports to guide you further. You...  Read Full »

A 21 year old male fainted suddenly after a party. Please guide us.

Query: Hello doctor, This query is regarding a 21 year old male having no health complications in the past who suddenly fainted after a party. We took him to our GP for the check up. The GP found nothing wrong and advised rest. However, we went to the lab on our own and carried out CBC. WBC count was high...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to The diagnosis in your case is lymphocytosis. The underlying cause for the lymphocytosis should be searched for. For that, a detailed physical examination should be done and liver, spleen and lymph nodes should be palpated. Infectious mononucleosis, viral influenza, h...  Read Full »

My blood reports shows lymphocytosis and macrocytic anemia. Kindly give your opinion.

Query: Hello doctor,I would like to know your opinion of my complete blood count. I have attached my reports with this which shows absolute lymphocytosis and macrocytic anemia from two years.   Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to the In the mentioned history hemoglobin level is low and MCV (mean corpuscular volume) is high, So macrocytic anemia is present (attachment removed to protect patient identity). The cause for which has to be ruled out. Hypothyroidism, vitamin B12 deficiency, liver di...  Read Full »

Would viral infection affect the lymphocyte and neutrophil values?

Query: Hi doctor, I had a viral infection last week. Is it normal to have increased lymphocyte levels of 52 % and decreased neutrophil levels of 35 % after having a viral infection? It got healed within a week. I was fine when I did my blood test. My RBC and WBC are considered to be normal. As I have anemi...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hi, Welcome to After having a viral infection, lymphocytosis can persist for seven to ten days. Your low neutrophils are relative, and it is because of increased lymphocytes. Platelet can be high because of inflammation or by iron deficiency anemia as a reactive thrombocytosis. Urinar...  Read Full »

My lymphocyte count is higher than normal, Do I have AIDS?

Query: Hello doctor, According to my CBC report, I am just above the normal lymphocyte count. Does this range come under lymphocytosis? Also, I have read that AIDS could be one of the causes of lymphocytosis. But, I am confused because I thought AIDS destroys lymphocytes, which causes lymphocytopenia. Ple...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to I read your query, and I can understand your concern.HIV (human immunodeficiency virus) infection reduces the lymphocyte count. However, HIV cannot be diagnosed by CBC(complete blood count) test.CMIA (chemiluminescent magnetic microparticle immunoassay) tests Or ELISA ...  Read Full »

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