Common "Mgus" queries answered by top doctors | iCliniq


MGUS (Monoclonal gammopathy of undetermined significance) refers to a condition in which the bone marrow produces an abnormal protein called monoclonal protein, or M-protein, in the blood. MGUS belongs to a spectrum of diseases known as plasma cell dyscrasias. It usually does not cause any problems, but people with MGUS have a higher risk of developing severe bone marrow disorders or some forms of cancer. However, if the disease does not progress, MGUS does not require any treatment.

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I have IgM MGUS without symptoms of WM. What is the further treatment?

Query: Hi doctor, I am 46 years old and I was diagnosed with IgM MGUS at low concentration last month. I am worried about the bone marrow results coming next week. My GP referred me to a hematologist. I do not have the symptoms of WM but hematologists suggest a bone marrow biopsy and CT scan excludes lymp...  Read Full »

Dr. Kamal Kant Sahu

Answer: Hi, Welcome to Based on the reports, you have IgM MGUS (monoclonal gammopathy of undetermined significance). But we need to confirm it by doing a bone marrow biopsy and it should be less than 10 percent clonal lymphoplasmacytic or plasma cells in the bone marrow. About one percent of pe...  Read Full »

Why is there low Hb and WBC in a MGUS patient?

Query: Hello doctor, I was diagnosed with MGUS earlier this year. My lab report states immunoglobulin M33, lambda free light chains 19.74, kappa or lambda light chain ratio 0.07. My doctor said there is a faint spike. Black bar on a grey background and to come back in a year. I have noticed that most of m...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to You have been diagnosed with MGUS problem (monoclonal gammopathy of undetermined significance). For that, no treatment has to be done except clinical monitoring. You are advised to investigate with serum urea, creatinine estimation, urine Bence Jones protein estimati...  Read Full »

What is the possible diagnosis for burning red palms and soles?

Query: Hello doctor, I was diagnosed with MGUS (IGA) when I was seeing a neurologist for some burning in my palms of my hands and soles of my feet which is awful at night and prohibits me from sleeping. This has been going on for six months but has gotten worse so I went back to the neurologist. Neurolog...  Read Full »

Dr. Kamal Kant Sahu

Answer: Hi, Welcome to I am sorry to hear with regards to your complaints and how much you are going through. I have seen your hand pictures. (attachment removed to protect patient identity). To be frank, it is really a tough case. There can be a few things that can be looked for: 1. Chron...  Read Full »

My husband has been diagnosed with MGUS 13 years back. His FLC ratio raised after a COVID infection. Is COVID affecting the FLC ratio?

Query: Hi doctor, My husband has been diagnosed with FLC MGUS (monoclonal gammopathy of undetermined significance) 13 years back. All laboratory test results were completely normal except for his FLC (free light chains) ratio. He is monitored annually. This January his FLC ratio raised from 12 to 21. He...  Read Full »

Dr. Rajesh Gulati

Answer: Hi, Welcome to I read your query and understand your concern. It is free kappa that is high. I hope you must have checked serum protein electrophoresis (SPE) for the M spike. If the M spike is negative, no treatment is needed at present. If the M spike is positive, you need treat...  Read Full »

Are elevated immunoglobulins in MGUS dangerous?

Query: Hello doctor, I have MGUS, and my bone marrow biopsy was taken a couple of years ago. My test results are as follows: free kappa LT chains: 35.2 mg/L, free lambda LT chains: 40.5 mg/L, immunoglobulin results 3,559 mg/L.Should I be worried?  Read Full »

Dr. Sugreev Singh

Answer: Hello, Welcome to Thank you for writing, and I understand your concern. Please send your reports, and I will go through them and let you know. It depends on your symptoms, so please let me know your symptoms. Since when have you been diagnosed with MGUS (monoclonal gammopathy of und...  Read Full »

I have been diagnosed with MGUS. Should I worry about it?

Query: Hi doctor, A hematologist has reviewed my reports, and I have been diagnosed with MGUS. My oncologist ordered the laboratories. I want a second opinion.  Read Full »

Dr. Mubashir Razzaq Khan

Answer: Hi, Welcome to MGUS (monoclonal gammopathy of undetermined significance) is an indolent type of disease with ups and downs in its course. It is now down, meaning no signs and symptoms and biochemical derangements have been detected. The only abnormality is a minute quantity of kappa-r...  Read Full »

What are the diagnostic tests to confirm MGUS?

Query: Hello doctor, I am a 53-year-old female. My BMI is 21. I have multiple complex symptoms over time, especially polyarthralgia, maculopapular body rashes, hypertension, photosensitivity, tension headaches, fatigue, bone and body pain, numerous infections in kidney, chest, ears, mouth, nose, bladder, ...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to According to history, you have been diagnosed with MGUS (monoclonal gammopathy of undetermined significance). But now, due to increased viscosity in blood by monoclonal paraproteins, you have symptoms like hypertension, headache, rash, etc. So as per my opinion, ...  Read Full »

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