Does COVID-19 have an impact on my husband's MGUS FLC test?

Question

Hi doctor,

My husband was diagnosed with FLC MGUS (monoclonal gammopathy of undetermined significance) 13 years ago. All laboratory test results were completely normal except for his FLC (free light chains) ratio. He is monitored annually. This FLC ratio rose from 12 to 21.

He had COVID-19. His haematologist suggested that we repeat because of COVID. Unfortunately, he got COVID again. We repeated the test, and they went up. Everything else, other than the FLC ratio, is completely normal.

Is COVID affecting this FLC test? I have all the test results and can submit them for your review.

Please help.

Thank you.

Answer 1

Hi,

Welcome to icliniq.com.

I read your query and understand your concern.

It is free kappa that is high. I hope you have checked serum protein electrophoresis (SPE) for the M spike. If the M spike is negative, no treatment is needed at present. If the M spike is positive, you need treatment.

If the M spike is negative, I suggest you repeat CBC (complete blood count), KFT (kidney function tests), serum free light chain ratio, and SPE for the M spike after three months.

I hope this helps.

Thank you.

Answer 2

Hi,

Welcome back to icliniq.com.

COVID can increase the ratio, but there is no proven data. Since the M spike is negative, you should not worry. No treatment is needed at present. But repeat the tests after three months.

I hope this helps.

Thank you.