My husband is getting peculiar symptoms every six months. What is it?

Hi,

Welcome to icliniq.com. I am sorry to know that no proper answers were extended by doctors for his condition. You are right in saying that this is unlikely an allergy problem as no allergy condition reappears after every six months. Also, there is no information about the duration of the problem once it appears, how it develops (gradual or sudden with all symptoms appearing at the same time) and how the remission takes place. But, I feel the following are possibilities- 1. Anxiety and stress - This is the most likely cause as symptoms are widely spread and distributed to five systems of the body (urinary, skin, gastrointestinal, nervous system and muscular system) and only little single disease can explain the symptoms. 2. An autoimmune disorder of mild severity- This is the other possible reason which can present through all systems. The age of onset and male gender point against it, but it is possible that it is of mild severity and do not stay longer because of the development of the body's defenses in the right direction. 3. Multiple sclerosis - Again male gender and age of onset point otherwise, but symptoms can be explained as multiple sclerosis (MS) present in episodic nature. It will be the right decision to go for MRI (magnetic resonance imaging) on next flare up.

Hi,

Welcome back to icliniq.com. I am glad to know that MS is ruled out as it is one of the deadliest disease. Regarding the autoimmune disorders it will be appropriate to get him investigated with antinuclear antibody, which is a simple test to screen for autoimmune disorders with high sensitivity. In case it comes positive, then he can be explored by further testing for various autoimmune disorders. I also like to add niacin deficiency in possible disease list. The niacin deficiency can cause exactly all symptoms as described by you and I think this should be tested. The chances are more as he faces diarrhea, which may be the reason or consequence of niacin deficiency. In case even if it turns out negative, then I suggest multivitamin supplements, especially during probable flare up months. I suggest a few things about stress. I see many patients who claim no stress, but on detailed evaluation multiple stressors are identified and respond well to therapies aimed at stress reduction. I do not mean the same is applicable for your husband, but keeping an open mind and accessing inner self is worth trying. Alike you, I am hopeful that some concrete evidence will be found to explain his symptoms and definite treatment.