Kindly give instructions to use Nicotinamide gel.

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It is recommended that you use Nicotinamide gel twice each day. If your skin becomes irritated or dry, then you can reduce the number of times, and use it to once daily, or even on alternate days only. The general point is that you should apply the gel to all of the areas where your spots occur and not just to each spot. Before you use the gel, wash the area with soap and lukewarm water and gently dry it with a towel. Then apply the gel and rub it in gently and do not wash the face after using. Leave it overnight to let it have the effect on theacne. As you apply the gel, try to avoid getting it on the sensitive areas of your skin in or around your nostrils, your eyes and your mouth. Do not apply it to any areas of skin which are irritated or sore.