Q. 28 year old unable to sustain respiration off the ventilator, why?

Answered by
Dr. Amol Kumar Wasudeorao Diwan
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Mar 24, 2016 and last reviewed on: Oct 17, 2022

Hi doctor,

My query is regarding a female patient aged 28 years. She has been on ventilator by means of a tracheostomy for 50 days. She has been on CPAP mode for two weeks, but unable to sustain respiration off the ventilator. Please help.



Welcome to

  • Young female on prolonged ventilator through tracheostomy and having difficulty in weaning is considered to be a very bad prognosis.
  • You have not mentioned proper medical history, indications for ventilation and under which medications she is on.
  • There are many things that we need to consider before removing the support of the ventilator. Weaning from the ventilator depends on the control of underlying causes.
  • With proper treatment of the underlying cause, weaning can be planned successfully.
  • Sometimes, the complications such as aspiration of fluids into the trachea and lung, collapse of lung, tracheal stenosis and resistant microorganisms are the main problems which will prevent successful weaning. So, treatment of the primary cause is very important.
  • With the use of proper antibiotics, good chest physiotherapy, proper ventilator settings and frequent suctioning we can plan to remove the ventilator.

Revert back with the asked details to a pulmonologist online -->

Hi doctor,

Thank you for your response. Patient, who is my wife, was admitted in ICU five months back after she became unresponsive in the general ward of the hospital, where she had been admitted the previous day for GERD and elevated BP. CT scan showed generalized cerebral edema and some infarction. The edema has been treated with diuretics. When initial weaning failed about eight days post ICU admission, a chest x-ray was done, which showed left lung collapse with pleural effusion in both lungs. Bilateral chest tubes were inserted in addition to antibiotic treatment. A tracheostomy was also done while she commenced daily physiotherapy. X-ray taken two weeks ago showed resolution of the lung, which has fully expanded. Chest tubes have been removed and there is good air movement on auscultation. But, patient is having challenge going off the ventilator. She has been on CPAP mode for nearly two weeks with intermittent attempts of weaning. Daily chest physiotherapy has been continued and she is on antibiotics. Tracheostomy is also frequently suctioned. She however cannot stay off for more than 30 minutes. There is agitation, sweating, elevation of BP to over 200/120 mmHg and partial loss of consciousness. It seems there is buildup of carbon dioxide (CO2) causing necrosis. Diaphragm and intercostal muscles seem to have suffered disuse atrophy.  I am seeking for help and alternate opinions on a guided approach to successfully weaning her off the ventilator. The intensivist here has put in quite some effort, but I feel we can do with some external help and guidance, hence I have come here. We are young couples. I am 30 years old and she is 28 now. We have two daughters, the last delivered just a week before she was admitted to hospital. Please help.



Welcome back to

Thanks for providing a detailed history which makes further planning easier.

  • As you said, there is no effusion and lungs are fully functional, we can try successful weaning as cerebral edema has also reduced.
  • What I can suggest now is, to give intermittent T-piece trials (tracheal intubation) and keep watching her oxygen saturation. If she is able to sustain it, slowly continuous positive airway pressure (CPAP) support can be reduced.
  • Along with this, good physiotherapy and constantly boosting her morale is very important. If there is no active underlying pathology, you can hope for successful weaning.
  • But, every time it does not happen as what exactly we think. So, do not get upset if this does not work. We are now in such a situation, where we have to accept the facts and hope for the best.
  • I hope intensive care unit (ICU) doctor is pretty experienced in handling such cases of difficult weaning. Because, there is much difference in just advising things from distance and actually treating the patient.

So, I hope everything will be fine soon and your wife will come out of this situation very soon. Hope the very best for you and your family.

For further queries consult a pulmonologist online -->

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