Can a PRP treatment for hair loss trigger Paget's disease?

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I understand your concern.

Paget's disease of the bone is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms. Many affected people have no family history of the disease, although it sometimes clusters in families. Studies suggest that close relatives of people with classic Paget disease of bone are seven to 10 times more likely to develop the disease than people without an affected relative. Early-onset Paget disease of bone is inherited in an autosomal dominant pattern. Therefore, in people with this disorder, having one altered copy of the TNFRSF11A gene in each cell is sufficient to cause the disease.

Many mutations in SQSTM1 (which encodes sequestosome-1, also known as ubiquitin-binding protein p62) account for the susceptibility to develop Paget's disease in some families; the involvement of other genes is currently under investigation. So it is hard to say how many chances you have to get it because your mother has it? How about your father if he had? You have more chance to get it as compared to the general public. If your father also had one, then your chances of getting it are nearly 25%. In addition to a genetic cause, environmental factors have been proposed to have a role in the pathogenesis of Paget's disease.

Although most evidence has been presented for the measles virus as an etiologic factor, some studies have not confirmed its involvement. Nevertheless, the decreasing incidence of Paget's disease, which could be attributed to measles vaccination along with the measles virus nucleocapsid protein induction of Paget's disease lesions in transgenic mice, supports an etiologic role of the virus. Regarding PRP (platelet-rich plasma) therapy, it does not increase the chances of getting it. There is no scientific evidence that it increases the chances of Paget's.

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Yes, you got it right. If both parents carry the abnormal gene, your chance of getting it is about 25 %. You can do genetic testing to know if your parents are carrying the gene. The SQSTM1 gene, which causes autosomal recessive patterns, can be checked. It is better to contact the genetic testing counseling team for further information about the test. I do not know which country you belong to and if these facilities are available there.

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In autosomal recessive disorders, individuals must have two disease alleles. Thus, both parents must either be affected or unaffected heterozygotes. If both parents are affected, all children will be affected. If both parents are unaffected heterozygotes, each child has a 25 % chance of being affected and a 50 % chance of being an unaffected heterozygous carrier of the disorder. Therefore, one-fourth of the offspring of two unaffected heterozygotes will carry two defective copies of the gene and will be affected. Half of the offspring will be heterozygous carriers of the disorder. Because heterozygotes are not affected, clinical manifestations of the disease are not seen in every generation. One parent is affected, and the other carrier will lead to a 50 % chance.

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As I was telling you last time as well. It is only 15 to 40 % through the autosomal recessive way. It can be sporadic as well. Having a family history increases the chances of other general public, but it is very hard to predict exactly how many chances you have. You can have genetic testing done. I can understand how worried you are, but it is impossible to predict it.

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The main spread is through autosomal recessive. But in people who get Pagets in an earlier life, it may be autosomal dominant, but that is very rare. PRP treatment does not have to do anything with Pagets.

I hope this has helped you. Thank you.