Dr. Sameer Kumar
MBBS., MS (OBS/GYNAE)., FMAS., DMAS., FELLOWSHIP IS ASSISTED REPRODUCTIVE TECHNIQUES
Infertility, Obstetrics And Gynaecology
Welcome back to icliniq.com.
Thanks for the prior history of treatment.
If tubes are blocked and Strassman's operation has been done, with a poor ovarian response to ovulation drugs, two failed IUI and then one failed IVF with two embryo transfer, then indeed I must say you have been patient and committed to the treatment.
Ideally speaking PRP therapy is offered to premature ovarian failure patients who have stopped producing eggs completely or whose follicle diameter is less than 4 mm at any time on follicular study. This is a modality to rejuvenate the ovarian tissue with autologous platelets, which release PDGF or platelet-derived growth factors, which in turn help in removing the scarred tissue and help in improving ovarian response by rejuvenation the scarred ovarian tissue. The follow-ups scans are important, and the therapeutic response may take even 12 weeks.
It is unlikely to cause any harm as the platelets are derived from your own blood and are autologous and hence there would be no rejection reaction as in blood transfusion or transplants. So, there is nothing to lose, you can surely give it a try.
I am adding some information for your perusal which shall help you understand the PRP modality better.
Platelets are very small components in their blood that generally help with clotting, but they are rich in growth factors and cytokines. These are in little granules within the platelets, and when you use platelet-rich plasma, the goal is to release these cytokines and growth factors into the tissue, which then help the tissue to regenerate. Under normal circumstances as tissue gets old, it gets replaced by fibrotic basically scar tissue. As ovaries age is they become like little clumps of scar tissue. In using platelet-rich plasma we hope that we can regenerate some of the normal ovarian tissue and not just that but regenerate vascularization, so there is an improved blood supply, and as a result hopefully restore some ovarian function.