Patient's Query
Hello doctor,
I am a 35-year-old female with PCOS (polycystic ovarian syndrome) now known as PMOS (polyendocrine metabolic ovarian syndrome) and struggling with obesity, BMI (body mass index) is 36. My insulin is high (fasting insulin 32 microunits per milliliter), and HOMA-IR (homeostatic model assessment insulin resistance) is elevated.
I am exhausted all the time despite normal thyroid labs. I have tried dieting, but nothing works long-term. Kindly tell me.
Could hormonal issues in women with PCOS make it harder to lose weight?
What treatments are safe for weight loss and preserving fertility?
Kindly help.
Thank you.
Hello,
Welcome to icliniq.com.
I read your query and can understand your concern.
The hormonal imbalances in PCOS (polycystic ovarian syndrome), now known as PMOS (polyendocrine metabolic ovarian syndrome), particularly high insulin levels, can make it harder to lose weight. Your elevated fasting insulin and HOMA-IR (homeostatic model assessment insulin resistance) suggest significant insulin resistance, which means your body is more likely to store fat and less efficient at burning it, even when you’re eating carefully.
This is not about willpower; it is a real metabolic issue that also explains your constant exhaustion, even with normal thyroid labs.
So, the good news is that there are safe, fertility-preserving treatments that can help. Medications like Metformin (medicine for high sugar) can lower insulin and support ovulation, while supplements like inositol have shown promise in improving insulin sensitivity and cycle regularity.
Newer options like GLP-1 (glucagon-like peptide-1) receptor agonists (like Semaglutide) are helping many women with PCOS lose weight and feel more energized, and they do not harm fertility; in fact, they often improve it.
Shifting to a low-carbohydrate or low-glycemic eating pattern and incorporating strength-based exercise can also make a big difference in your life. The key is to stop focusing on just cutting calories and instead work with your hormones and metabolism. You are definitely not alone in this, and with the right approach, things can get better both for your energy and your long-term health.
I hope this information helps you.
Feel free to ask further queries.
Thank you.
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Answered byDr. Ashraf Ghani
Medically reviewed byiCliniq medical review team
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