After taking Humira for Crohn's, my prostatitis and testicular pain got worse. Why?

Hello doctor,

I am on Humira weekly for Crohn's. I just finished a few weeks ago, a nine week course of Encort and on my last week of rectal uceris both steroids. My symptoms are testicular pain, burning during and after urination, groin pain, scrotal pain, pain at the base of penis, frequent urination, bladder spasms, difficulty starting stream, more than one stream. Past history of BPH and prostititis. PCP started me on Ciprofloxacin for 10 days. My WBC is 9.2, monocyte% 9.1, creatinine 1.3, and urine was colorless and clear. I took Huimra injection and symptoms increased so put me on 10 days of Doxycycline for burning urination. I felt worse on Humira and put on Levofloxacin for 10 days. I have increased testicle pain due to riding a bike but no injury. Doctor did an exam of my testicles and sent me for UA, and testicular ultrasound. During the ultrasound, I had to stop three times to urinate even though very little amount but extreme urgency. That night I kept having bladder spams felt like the head of my penis was quivering and would not stop until I urinate. My blood work shows, WBC 10.7, monocyctes % 13.2, absolute monocyte 1.4.

Urine report is fine. Ultrasound shows small bilateral epididymal cysts. Small bilateral hydroceles. No varicocele. I am also taking Tylenon severe sinus daily if not twice a day for months due to constant sinusitis from Humira. This was all while on antibiotics Current symptoms are improving we skipped a dose of Humira due to the increase in symptoms but taking tomorrow. I have pain in penis, testicle and base of penis, burning with urination, urgency and frequency getting better while on Flavoxate. I saw a new urologist a few weeks ago. He said prostrate was fine, nothing wrong with testicles, prostate was not enlarged even though multiple CT scans, PCP 2 other urologsit and a cystoscope say different. He said I need to train my bladder and told me to stop the Flomax which has been on for years.

I talked to my PCP and he said to do nothing that he would call the urologsit and see what he was thinking because he said the CT show enlarged prostate when he had done prostate exam in the past it was enlarged which is why he first sent me to a urologist and all urologist reports say enlarged prostate. Would Humira make prostatitis worse after an injection? Why are antibiotics helping but not getting cured fully?

Thank you dcotor,

The medicines are helping to some extent. My stream is stronger, going less often. As long as I take Fluvoxate regualry, I do not have to run to the bathroom all the time. However, I still have burning with urination, testicle pain, and pain in the head of the penis. BM makes everything worse. If Humiria makes things worse what do I do? After all these antibiotics would it have been better to stick with one? What else can the urologist do that the PCP is not doing? Is a prostate exam necessary if Humira makes worse or no because we know what it is? PCP has not done a prostate exam for a few years on me. I have done internal pelvic floor PT and it has helped but PCP said we need to find out first what is going on. If not prostatitis what can it be?