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What could cause elevated protein levels in the urine?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hi doctor,

I am a 66 year male, who is diabetic and hypertensive from the last 15 years. I am on Tazloc H, Cresar AM, Metformin, and Amaryl. Routine urine exam showed proteins 30 mg/L, micro albumin 94.97 mg/L, and pus cells 4 to 5 cells. What is the inference and advise?

Hi,

Welcome to icliniq.com.

I will advise you to check UPCR (urine protein to creatinine ratio) and evaluate fundus for diabetic retinopathy or hypertension retinopathy. Thanks.

Patient's Query

Hi doctor,

Thank you for replying.

Would you suggest a repeat urine analysis before UACR?

Is this amount of protein worrisome? How soon should I be investigated in this scenario?

I am attaching all my reports. Kindly advise.

Hi,

Welcome back to icliniq.com.

From the reports (attachments removed to protect patient's identity), it seems that kidney function is normal. Protein more than 300 mg/day is worrisome. To rule out the effect of diabetes on kidneys, check your retina because 70 % (percent) of retinopathy have nephropathy. And if the retina is normal, there are fewer chances of affection of kidney due to DM (diabetes mellitus).

I will advise you to do 24-hour urine protein for better prediction, ultrasound KUB (kidney, ureter, and bladder), and renal artery Doppler.

Revert with the above information, and feel free to ask any query.

Patient's Query

Hi doctor,

Please go through the reports and advise if the ACR looks fine?

I was a little skeptical about the ratio calculations.

I am attaching the recent reports as well as the previous ones for your perusal.

Hi,

Welcome back to icliniq.com.

I saw your reports (attachments removed to protect the patient's identity).

UACR (urine albumin-to-creatinine ratio) is normal.

Target HbA1c upto 7.5%.

Take the tablet Febustat 40 mg if liver function and serum uric acid level are normal.

If you have any symptoms, get the fundus checked.

Medically reviewed byiCliniq medical review team

Published At July 23, 2017
Reviewed AtApril 16, 2025

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